[更年期期间体重增加与代谢综合征的组成部分]

[Gaining weight and components of metabolic syndrome in the period of menopause].

作者信息

Simoncig-Netjasov Aleksandra, Vujović Svetlana, Ivović Miomira, Tancić-Gajić Milina, Drezgić Milka

出版信息

Srp Arh Celok Lek. 2008 Sep-Oct;136(9-10):505-13. doi: 10.2298/sarh0810505s.

DOI:10.2298/sarh0810505s

PMID:19069342

Abstract

INTRODUCTION

Menopause induces redistribution of fat mass and development of abdominal obesity, increasing risk for metabolic syndrome (MS) by 60%. Related cardiovascular diseases become a leading cause of morbidity and mortality in women after fifty years of age.

OBJECTIVE

The aim of this study was to investigate the influence of gaining weight on components of MS in the menopause.

METHOD

The study included 50 obese women, BMI=31.92 +/- 5.83 kg/m2, age 54.40 +/- 3.64, time since menopause 5.90 +/- 5.46 years, and 37 normal weight women, BMI = 23.50 +/- 2.13 kg/m2, age 53.92 +/- 3.95, time since menopause 5.96 +/- 4.92 years. Both groups were divided according to the presence of MS into two subgroups. Anthropometric characteristics and blood pressure were measured. Blood was taken at 8 am for the following: fasting glucose, triglycerides, cholesterol, HDL, LDL, apolipoprotein A (ApoA), apolipoprotein B (ApoB), lipoprotein(a) (Lp(a)), C-reactive protein (CRP), fibrinogen, FSH, LH, prolactin, oestrogen, progesterone, testosterone and sex hormone-binding globulin (SHBG).

RESULTS

66% of obese women had MS compared with 22% normal weight women. Significant differences between groups were found for the following: weight, BMI, waist, hip circumference, waist/hip ratio, diastolic blood pressure, Lp(a), FSH, LH, prolactin (all p < 0.01) and fasting glucose (p < 0.05). Obese women with and without MS were significantly diverse for the following: waist/hip ratio, systolic blood pressure and fasting glucose (all p < 0.01); age, BMI, waist circumference, triglycerides, HDL, Lp(a) and SHBG (all p < 0.05). Normal weight women with and without MS had significantly different values of waist/hip ratio, systolic, diastolic blood pressure, triglycerides (all p < 0.01); HDL and testosterone (p < 0.05). Significant differences were found between obese and normal weight women with MS in anthropometric characteristics, ApoA, Lp(a), fibrinogen (all p < 0.01) and FSH (p < 0.05).

CONCLUSION

Abdominal obesity significantly increases incidence of MS as a cluster of cardiovascular risk factors in the menopause.

摘要

引言

绝经会导致脂肪分布重新调整以及腹部肥胖的出现，使患代谢综合征（MS）的风险增加60%。相关的心血管疾病成为50岁以上女性发病和死亡的主要原因。

目的

本研究旨在探讨体重增加对绝经后MS各组成成分的影响。

方法

该研究纳入了50名肥胖女性，体重指数（BMI）=31.92±5.83kg/m²，年龄54.40±3.64岁，绝经时间5.90±5.46年，以及37名体重正常的女性，BMI = 23.50±2.13kg/m²，年龄53.92±3.95岁，绝经时间5.96±4.92年。两组均根据是否患有MS分为两个亚组。测量人体测量学特征和血压。上午8点采集血液检测以下指标：空腹血糖、甘油三酯、胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A（ApoA）、载脂蛋白B（ApoB）、脂蛋白(a)（Lp(a)）、C反应蛋白（CRP）、纤维蛋白原、促卵泡激素（FSH）、促黄体生成素（LH）、催乳素、雌激素、孕酮、睾酮和性激素结合球蛋白（SHBG）。

结果

66%的肥胖女性患有MS，而体重正常的女性中这一比例为22%。两组在以下方面存在显著差异：体重、BMI、腰围、臀围、腰臀比、舒张压、Lp(a)、FSH、LH、催乳素（均p < 0.01）和空腹血糖（p < 0.05）。患有和未患有MS的肥胖女性在以下方面存在显著差异：腰臀比、收缩压和空腹血糖（均p < 0.01）；年龄、BMI、腰围、甘油三酯、HDL、Lp(a)和SHBG（均p < 0.05）。患有和未患有MS的体重正常女性在腰臀比、收缩压、舒张压、甘油三酯（均p < 0.01）；HDL和睾酮（p < 0.05）方面存在显著不同的值。患有MS的肥胖女性和体重正常女性在人体测量学特征、ApoA、Lp(a)、纤维蛋白原（均p < 0.01）和FSH（p < 0.05）方面存在显著差异。