[皮肤型结节性多动脉炎与克罗恩病：一种不容忽视的关联]
[Cutaneous polyarteritis nodosa and Crohn's disease: An association not to be ignored].
作者信息
Magnant J, Lhommet C, Machet L, Machet M-C, Guilmot J-L, Diot E
机构信息
Service de médecine interne B, hôpital Bretonneau, université François-Rabelais, CHRU de Tours, 2 bis, boulevard Tonnellé, 37044 Tours, France.
出版信息
Rev Med Interne. 2009 Apr;30(4):345-8. doi: 10.1016/j.revmed.2008.10.335. Epub 2008 Dec 13.
INTRODUCTION
Cutaneous polyarteritis nodosa (CPAN) is an entity which needs to be acknowledged, since it can have a spontaneously adverse outcome. We report two cases of CPAN associated with Crohn's disease.
CASE REPORTS
The first patient was suffering from Crohn's disease for 9 years when she was referred for a necrotic toe. A diagnosis of necrotizing angeitis was confirmed by histological examination of a skin biopsy. Despite systemic corticosteroids, the lesions became more severe, requiring immunosuppressive treatment. The second patient was a female patient referred with forefoot ischemia. Cutaneous histology confirmed the diagnosis of necrotizing angeitis that responded favourably to corticosteroid treatment. The patient had been diagnosed with Crohn's disease 2 months previously.
CONCLUSION
CPAN differed from systemic PAN by the absence of visceral involvement. Its association with Crohn's disease, although uncommon, must be recognized as it affects treatment and monitoring.
引言
皮肤型结节性多动脉炎（CPAN）是一种需要被认识的疾病，因为它可能会有自发的不良后果。我们报告两例与克罗恩病相关的CPAN病例。
病例报告
首例患者患克罗恩病9年后因趾部坏死前来就诊。皮肤活检的组织学检查确诊为坏死性血管炎。尽管使用了全身性皮质类固醇，但病变仍加重，需要免疫抑制治疗。第二例患者是一名因前足缺血前来就诊的女性患者。皮肤组织学检查确诊为坏死性血管炎，对皮质类固醇治疗反应良好。该患者在就诊前2个月被诊断为克罗恩病。
结论
CPAN与系统性多动脉炎（PAN）的不同之处在于无内脏受累。其与克罗恩病的关联虽不常见，但因其影响治疗和监测，必须予以认识。
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