Goslen J B, Graham W, Lazarus G S
Arch Dermatol. 1983 Apr;119(4):326-9. doi: 10.1001/archderm.119.4.326.
A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.
一名患者患有与克罗恩病相关的皮肤结节性多动脉炎。免疫病理学研究显示，通过C1q结合检测到循环免疫复合物的证据。病变皮肤的免疫荧光显微镜检查显示C3和纤维蛋白沉积。对正常皮肤进行组胺注射，随后的活检标本及免疫荧光显微镜检查显示有免疫沉积物。该患者接受了环磷酰胺和泼尼松治疗，临床反应良好，但两年内发生了组织细胞淋巴瘤。皮肤结节性多动脉炎与克罗恩病之间存在关联，而且免疫抑制治疗在组织细胞淋巴瘤的发生中起作用。
