晶状体中间丝。
Lens intermediate filaments.
作者信息
FitzGerald Paul G
机构信息
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA.
出版信息
Exp Eye Res. 2009 Feb;88(2):165-72. doi: 10.1016/j.exer.2008.11.007. Epub 2008 Nov 24.
Abstract
The ocular lens assembles two separate intermediate filament systems sequentially with differentiation. Canonical 8-11 nm IFs composed of Vimentin are assembled in lens epithelial cells and younger fiber cells, while the fiber cell-specific beaded filaments are switched on as fiber cell elongation initiates. Some of the key features of both filament systems are reviewed.
摘要
晶状体随着分化过程依次组装两个独立的中间丝系统。由波形蛋白组成的典型的8 - 11纳米中间丝在晶状体上皮细胞和较年轻的纤维细胞中组装，而纤维细胞特异性的串珠状丝在纤维细胞开始伸长时开启。本文综述了这两种丝系统的一些关键特征。
相似文献
1
Lens intermediate filaments.
Exp Eye Res. 2009 Feb;88(2):165-72. doi: 10.1016/j.exer.2008.11.007. Epub 2008 Nov 24.
2
Development- and differentiation-dependent reorganization of intermediate filaments in fiber cells.
Invest Ophthalmol Vis Sci. 2001 Mar;42(3):735-42.
3
The beaded intermediate filaments and their potential functions in eye lens.
Bioessays. 1994 Jun;16(6):413-8. doi: 10.1002/bies.950160609.
4
Filensin and phakinin form a novel type of beaded intermediate filaments and coassemble de novo in cultured cells.
J Cell Biol. 1996 Feb;132(4):643-55. doi: 10.1083/jcb.132.4.643.
5
Periplakin interactions with lens intermediate and beaded filaments.
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1283-9. doi: 10.1167/iovs.08-2894. Epub 2008 Nov 21.
6
Seeing is believing! The optical properties of the eye lens are dependent upon a functional intermediate filament cytoskeleton.
Exp Cell Res. 2005 Apr 15;305(1):1-9. doi: 10.1016/j.yexcr.2004.11.021. Epub 2005 Jan 26.
7
Functions of the intermediate filament cytoskeleton in the eye lens.
J Clin Invest. 2009 Jul;119(7):1837-48. doi: 10.1172/JCI38277. Epub 2009 Jul 1.
8
Expression of the type VI intermediate filament proteins CP49 and filensin in the mouse lens epithelium.
Mol Vis. 2016 Aug 6;22:970-89. eCollection 2016.
9
Resisting the effects of aging: a function for the fiber cell beaded filament.
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1030-6. doi: 10.1167/iovs.07-1149.
10
Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation.
J Cell Sci. 1995 Apr;108 ( Pt 4):1397-406. doi: 10.1242/jcs.108.4.1397.
引用本文的文献
1
CD24 is required for sustained transparency of the adult lens.
Exp Eye Res. 2025 Jun;255:110347. doi: 10.1016/j.exer.2025.110347. Epub 2025 Mar 18.
2
Tissue, cellular, and molecular level determinants for eye lens stiffness and elasticity.
Front Ophthalmol (Lausanne). 2024 Aug 8;4:1456474. doi: 10.3389/fopht.2024.1456474. eCollection 2024.
3
The significance of growth shells in development of symmetry, transparency, and refraction of the human lens.
Front Ophthalmol (Lausanne). 2024 Jul 19;4:1434327. doi: 10.3389/fopht.2024.1434327. eCollection 2024.
4
Aging of the eye: Lessons from cataracts and age-related macular degeneration.
Ageing Res Rev. 2024 Aug;99:102407. doi: 10.1016/j.arr.2024.102407. Epub 2024 Jul 6.
5
Aquaporin-0-protein interactions elucidated by crosslinking mass spectrometry.
Biochem Biophys Res Commun. 2024 Oct 1;727:150320. doi: 10.1016/j.bbrc.2024.150320. Epub 2024 Jun 27.
6
Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation.
Dev Biol. 2023 Dec;504:25-37. doi: 10.1016/j.ydbio.2023.09.005. Epub 2023 Sep 16.
7
Effects of truncations in the N- and C-terminal domains of filensin on filament formation with phakinin in cell-free conditions and cultured cells.
FEBS Open Bio. 2023 Nov;13(11):1990-2004. doi: 10.1002/2211-5463.13700. Epub 2023 Aug 30.
8
Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix.
Cells. 2023 Jun 7;12(12):1580. doi: 10.3390/cells12121580.
9
Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts.
Indian J Ophthalmol. 2023 May;71(5):2143-2151. doi: 10.4103/IJO.IJO_3269_22.
10
Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency.
Biomolecules. 2023 Apr 19;13(4):693. doi: 10.3390/biom13040693.
本文引用的文献
1
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching.
Mol Vis. 2008 Jul 10;14:1282-7.
2
Identification of a novel intermediate filament-linked N-cadherin/gamma-catenin complex involved in the establishment of the cytoarchitecture of differentiated lens fiber cells.
Dev Biol. 2008 Jul 15;319(2):298-308. doi: 10.1016/j.ydbio.2008.04.036. Epub 2008 May 8.
3
Resisting the effects of aging: a function for the fiber cell beaded filament.
Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1030-6. doi: 10.1167/iovs.07-1149.
4
A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens.
J Biol Chem. 2008 Mar 7;283(10):6607-15. doi: 10.1074/jbc.M709144200. Epub 2008 Jan 3.
5
Identifying the role of specific motifs in the lens fiber cell specific intermediate filament phakosin.
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5132-41. doi: 10.1167/iovs.07-0647.
6
Cytolinker cross-talk: periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migration.
Exp Cell Res. 2007 Oct 1;313(16):3579-91. doi: 10.1016/j.yexcr.2007.07.005. Epub 2007 Jul 14.
7
Structural specializations emerging late in mouse lens fiber cell differentiation.
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3269-76. doi: 10.1167/iovs.07-0109.
8
Plakins in development and disease.
Exp Cell Res. 2007 Jun 10;313(10):2189-203. doi: 10.1016/j.yexcr.2007.03.039. Epub 2007 Apr 19.
9
The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta.
Development. 2007 May;134(9):1809-17. doi: 10.1242/dev.02843. Epub 2007 Apr 4.
10
Autosomal recessive juvenile onset cataract associated with mutation in BFSP1.
Hum Genet. 2007 May;121(3-4):475-82. doi: 10.1007/s00439-006-0319-6. Epub 2007 Jan 16.
Zotero 插件