中间丝细胞骨架在晶状体中的功能。
Functions of the intermediate filament cytoskeleton in the eye lens.
作者信息
Song Shuhua, Landsbury Andrew, Dahm Ralf, Liu Yizhi, Zhang Qingjiong, Quinlan Roy A
机构信息
Center for Ophthalmic Research/Surgery, Brigham and Women's Hospital, and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Clin Invest. 2009 Jul;119(7):1837-48. doi: 10.1172/JCI38277. Epub 2009 Jul 1.
Abstract
Intermediate filaments (IFs) are a key component of the cytoskeleton in virtually all vertebrate cells, including those of the lens of the eye. IFs help integrate individual cells into their respective tissues. This Review focuses on the lens-specific IF proteins beaded filament structural proteins 1 and 2 (BFSP1 and BFSP2) and their role in lens physiology and disease. Evidence generated in studies in both mice and humans suggests a critical role for these proteins and their filamentous polymers in establishing the optical properties of the eye lens and in maintaining its transparency. For instance, mutations in both BFSP1 and BFSP2 cause cataract in humans. We also explore the potential role of BFSP1 and BFSP2 in aging processes in the lens.
摘要
中间丝（IFs）几乎是所有脊椎动物细胞（包括眼晶状体细胞）细胞骨架的关键组成部分。中间丝有助于将单个细胞整合到各自的组织中。本综述重点关注晶状体特异性中间丝蛋白珠状丝结构蛋白1和2（BFSP1和BFSP2）及其在晶状体生理和疾病中的作用。在小鼠和人类研究中产生的证据表明，这些蛋白质及其丝状聚合物在建立眼晶状体的光学特性和维持其透明度方面起着关键作用。例如，BFSP1和BFSP2的突变都会导致人类白内障。我们还探讨了BFSP1和BFSP2在晶状体老化过程中的潜在作用。
相似文献
1
Functions of the intermediate filament cytoskeleton in the eye lens.中间丝细胞骨架在晶状体中的功能。
J Clin Invest. 2009 Jul;119(7):1837-48. doi: 10.1172/JCI38277. Epub 2009 Jul 1.
2
Seeing is believing! The optical properties of the eye lens are dependent upon a functional intermediate filament cytoskeleton.眼见为实！晶状体的光学特性取决于功能性中间丝细胞骨架。
Exp Cell Res. 2005 Apr 15;305(1):1-9. doi: 10.1016/j.yexcr.2004.11.021. Epub 2005 Jan 26.
3
Insights into the beaded filament of the eye lens.对晶状体串珠状细丝的深入了解。
Exp Cell Res. 2007 Jun 10;313(10):2180-8. doi: 10.1016/j.yexcr.2007.04.005. Epub 2007 Apr 6.
4
The beaded intermediate filaments and their potential functions in eye lens.串珠状中间丝及其在晶状体中的潜在功能。
Bioessays. 1994 Jun;16(6):413-8. doi: 10.1002/bies.950160609.
5
Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.去除热休克因子4（Hsf4）会通过下调γ-S晶状体蛋白和Bfsp的表达导致小鼠白内障形成。
BMC Mol Biol. 2009 Feb 19;10:10. doi: 10.1186/1471-2199-10-10.
6
Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton.在小鼠129品系中发现的Bfsp2突变导致CP49缺失，并诱导晶状体纤维细胞细胞骨架中波形蛋白依赖性变化。
Exp Eye Res. 2004 Jan;78(1):109-23. doi: 10.1016/j.exer.2003.09.001.
7
Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract.中间丝蛋白CP49的敲除会破坏晶状体纤维细胞的细胞骨架并降低晶状体的光学质量，但不会诱发白内障。
Exp Eye Res. 2003 Mar;76(3):385-91. doi: 10.1016/s0014-4835(02)00330-5.
8
The intermediate filament cytoskeleton of the lens: an ever changing network through development and differentiation. A minireview.晶状体的中间丝细胞骨架：在发育和分化过程中不断变化的网络。一篇小型综述。
Ophthalmic Res. 1996;28 Suppl 1:58-61. doi: 10.1159/000267946.
9
Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton.在小鼠129品系中发现的Bfsp2突变导致CP49'缺失，并诱导晶状体纤维细胞细胞骨架中波形蛋白依赖性变化。
Exp Eye Res. 2004 Apr;78(4):875-89. doi: 10.1016/j.exer.2003.09.028.
10
Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens.Tmod1 和 CP49 协同作用，控制着小鼠晶状体的纤维细胞几何形状、透明度和机械硬度。
PLoS One. 2012;7(11):e48734. doi: 10.1371/journal.pone.0048734. Epub 2012 Nov 7.
引用本文的文献
1
Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.中间丝蛋白BFSP1通过调节纺锤体长度维持卵母细胞不对称分裂。
Adv Sci (Weinh). 2025 Jul;12(28):e2504066. doi: 10.1002/advs.202504066. Epub 2025 May 11.
2
Differential Signaling Pathways Identified in Aqueous Humor, Anterior Capsule, and Crystalline Lens of Age-Related, Diabetic, and Post-Vitrectomy Cataract.在年龄相关性、糖尿病性和玻璃体切除术后白内障的房水、前囊膜和晶状体中鉴定出的差异信号通路。
Proteomes. 2025 Feb 3;13(1):7. doi: 10.3390/proteomes13010007.
3
Human lens epithelial cells induce the inflammatory response when placed into the lens capsular bag model of posterior capsular opacification.当人晶状体上皮细胞被置于后囊膜混浊的晶状体囊袋模型中时，会引发炎症反应。
Mol Vis. 2024 Oct 8;30:348-367. eCollection 2024.
4
From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease.从细胞结构到线粒体信号传导：中间丝在健康、衰老和疾病中的作用
Int J Mol Sci. 2025 Jan 27;26(3):1100. doi: 10.3390/ijms26031100.
5
Intermediate filaments and their associated molecules.中间丝及其相关分子。
J Biomed Res. 2025 Feb 8;39(3):242-253. doi: 10.7555/JBR.38.20240193.
6
Genomic signatures of sensory adaptation and evolution in pangolins.穿山甲感觉适应与进化的基因组特征
BMC Genomics. 2024 Dec 4;25(1):1176. doi: 10.1186/s12864-024-11063-x.
7
Application of transgenic mice to the molecular pathogenesis of cataract.转基因小鼠在白内障分子发病机制中的应用。
Int J Ophthalmol. 2024 Oct 18;17(10):1929-1948. doi: 10.18240/ijo.2024.10.21. eCollection 2024.
8
Tissue, cellular, and molecular level determinants for eye lens stiffness and elasticity.晶状体硬度和弹性的组织、细胞及分子水平决定因素。
Front Ophthalmol (Lausanne). 2024 Aug 8;4:1456474. doi: 10.3389/fopht.2024.1456474. eCollection 2024.
9
The significance of growth shells in development of symmetry, transparency, and refraction of the human lens.生长线在人晶状体对称性、透明度和屈光发育中的意义。
Front Ophthalmol (Lausanne). 2024 Jul 19;4:1434327. doi: 10.3389/fopht.2024.1434327. eCollection 2024.
10
Aquaporin-0-protein interactions elucidated by crosslinking mass spectrometry.水通道蛋白-0 蛋白相互作用的交联质谱解析。
Biochem Biophys Res Commun. 2024 Oct 1;727:150320. doi: 10.1016/j.bbrc.2024.150320. Epub 2024 Jun 27.
本文引用的文献
1
Dominant cataract formation in association with a vimentin assembly disrupting mutation.与波形蛋白组装破坏突变相关的显性白内障形成
Hum Mol Genet. 2009 Mar 15;18(6):1052-7. doi: 10.1093/hmg/ddn440. Epub 2009 Jan 6.
2
Structural function of MIP/aquaporin 0 in the eye lens; genetic defects lead to congenital inherited cataracts.眼晶状体中MIP/水通道蛋白0的结构功能；基因缺陷导致先天性遗传性白内障。
Handb Exp Pharmacol. 2009(190):265-97. doi: 10.1007/978-3-540-79885-9_14.
3
Periplakin interactions with lens intermediate and beaded filaments.外周斑蛋白与晶状体中间丝和串珠状丝的相互作用。
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1283-9. doi: 10.1167/iovs.08-2894. Epub 2008 Nov 21.
4
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival.E-钙黏蛋白和N-钙黏蛋白在晶状体泡分离和晶状体上皮细胞存活过程中的协同作用。
Dev Biol. 2009 Feb 15;326(2):403-17. doi: 10.1016/j.ydbio.2008.10.011. Epub 2008 Nov 1.
5
A new mutation in BFSP2 (G1091A) causes autosomal dominant congenital lamellar cataracts.BFSP2基因中的一个新突变（G1091A）导致常染色体显性先天性板层白内障。
Mol Vis. 2008;14:1906-11. Epub 2008 Oct 24.
6
A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice.一种显性波形蛋白突变体上调热休克蛋白70（Hsp70）和泛素-蛋白酶体系统的活性，并在转基因小鼠中导致后发性白内障。
J Cell Sci. 2008 Nov 15;121(Pt 22):3737-46. doi: 10.1242/jcs.030312. Epub 2008 Oct 21.
7
Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping.利用连锁分析和连锁不平衡定位法在3号染色体3q26上鉴定并验证三个新的近视常见易感基因位点
PLoS Genet. 2008 Oct;4(10):e1000220. doi: 10.1371/journal.pgen.1000220. Epub 2008 Oct 10.
8
Mallory-Denk-bodies: lessons from keratin-containing hepatic inclusion bodies.马洛里-丹科小体：含角蛋白的肝脏包涵体的启示
Biochim Biophys Acta. 2008 Dec;1782(12):764-74. doi: 10.1016/j.bbadis.2008.08.008. Epub 2008 Sep 6.
9
Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition.老花眼。从模糊认知走向对这种最常见眼部疾病分子基础的理解。
Exp Eye Res. 2009 Feb;88(2):241-7. doi: 10.1016/j.exer.2008.07.003. Epub 2008 Jul 15.
10
Distribution of basal membrane complex components in elongating lens fibers.基底膜复合体成分在伸长晶状体纤维中的分布。
Mol Vis. 2008 Jun 30;14:1187-203.
Zotero 插件