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生长线在人晶状体对称性、透明度和屈光发育中的意义。

The significance of growth shells in development of symmetry, transparency, and refraction of the human lens.

作者信息

Greiling Teri M, Clark Judy M, Clark John I

机构信息

Department of Dermatology, School of Medicine, Oregon Health & Science University, Portland, OR, United States.

Department of Biological Structure, University of Washington, Seattle, WA, United States.

出版信息

Front Ophthalmol (Lausanne). 2024 Jul 19;4:1434327. doi: 10.3389/fopht.2024.1434327. eCollection 2024.

DOI:10.3389/fopht.2024.1434327
PMID:39100140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11294239/
Abstract

Human visual function depends on the biological lens, a biconvex optical element formed by coordinated, synchronous generation of growth shells produced from ordered cells at the lens equator, the distal edge of the epithelium. Growth shells are comprised of straight (St) and S-shaped (SSh) lens fibers organized in highly symmetric, sinusoidal pattern which optimizes both the refractile, transparent structure and the unique microcirculation that regulates hydration and nutrition over the lifetime of an individual. The fiber cells are characterized by diversity in composition and age. All fiber cells remain interconnected in their growth shells throughout the life of the adult lens. As an optical element, cellular differentiation is constrained by the physical properties of light and its special development accounts for its characteristic symmetry, gradient of refractive index (GRIN), short range transparent order (SRO), and functional longevity. The complex sinusoidal structure is the basis for the lens microcirculation required for the establishment and maintenance of image formation.

摘要

人类视觉功能依赖于生物晶状体，这是一种双凸光学元件，由晶状体赤道（上皮细胞的远端边缘）处有序细胞同步生成的生长壳协调形成。生长壳由以高度对称的正弦模式排列的直形（St）和S形（SSh）晶状体纤维组成，这种模式优化了折射、透明结构以及在个体生命周期中调节水合作用和营养的独特微循环。纤维细胞的特征在于组成和年龄的多样性。在成年晶状体的整个生命过程中，所有纤维细胞在其生长壳中保持相互连接。作为一种光学元件，细胞分化受到光的物理特性的限制，其特殊的发育解释了其特征对称性、折射率梯度（GRIN）、短程透明有序（SRO）和功能寿命。复杂的正弦结构是建立和维持图像形成所需的晶状体微循环的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/74ee880044b9/fopht-04-1434327-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/c61359419604/fopht-04-1434327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/291b38821dc4/fopht-04-1434327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/aca11c31b5c7/fopht-04-1434327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/6faca966b0e9/fopht-04-1434327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/9d26910f2c3a/fopht-04-1434327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/b1f2d614d567/fopht-04-1434327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/74ee880044b9/fopht-04-1434327-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/c61359419604/fopht-04-1434327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/291b38821dc4/fopht-04-1434327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/aca11c31b5c7/fopht-04-1434327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/6faca966b0e9/fopht-04-1434327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/9d26910f2c3a/fopht-04-1434327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/b1f2d614d567/fopht-04-1434327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1754/11294239/74ee880044b9/fopht-04-1434327-g007.jpg

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