Anderson Laura L, Woerpel K A
Department of Chemistry, University of California, Irvine, California 92697, USA.
Org Lett. 2009 Jan 15;11(2):425-8. doi: 10.1021/ol802412b.
The copper-catalyzed insertions of nitriles into the Si-C bonds of silacyclopropenes provide azasilacyclopentadienes, which can be converted to allylic amines after reduction and protodesilylation. The enamine functionality of azasilacyclopentadienes also participates in 1,4-addition reactions and undergoes a hydroboration and oxidation sequence to form an allylic 1,2-amino alcohol.
铜催化腈插入硅环丙烯的Si-C键中可生成氮杂硅环戊二烯,经还原和去甲硅烷基化后可转化为烯丙基胺。氮杂硅环戊二烯的烯胺官能团也参与1,4-加成反应,并经过硼氢化和氧化序列形成烯丙基1,2-氨基醇。