Schindelmeiser J, Gullotta F
Institute of Anatomy, Westfälische Wilhelms-Universität Münster, Germany.
Clin Neuropathol. 1991 May-Jun;10(3):109-11.
The central nervous system of HIV-seropositive patients with and without AIDS-encephalopathy was investigated by immunocytochemistry using the monoclonal antibody to the HIV-1 p24 core protein. Numerous p24-immunopositive mono- and multinucleated macrophages could only be detected in patients with typical histological pictures of an AIDS-encephalopathy. These findings allow the supposition that AIDS-dementia is a result of a relatively late infiltration of HIV-infected macrophages from the bloodstream into the brain and is not due to an impairment of neuronal and/or glial cells infected by HIV during the early stage of the disease.
使用针对HIV-1 p24核心蛋白的单克隆抗体，通过免疫细胞化学方法对患有和未患有艾滋病脑病的HIV血清阳性患者的中枢神经系统进行了研究。仅在具有典型艾滋病脑病组织学图像的患者中检测到大量p24免疫阳性的单核和多核巨噬细胞。这些发现表明，艾滋病痴呆是HIV感染的巨噬细胞相对较晚从血液中浸润到大脑的结果，而不是由于疾病早期被HIV感染的神经元和/或神经胶质细胞受损所致。
