Guan Zheng-Hui, Huang Kexuan, Yu Shichao, Zhang Xumu
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Org Lett. 2009 Jan 15;11(2):481-3. doi: 10.1021/ol802665v.
Enamides were efficiently prepared via a novel Rh/C-catalyzed direct hydroacylation of ketoximes. Up to 88% isolated yield of enamides were obtained with this method. Subsequent asymmetric hydrogenation of the enamides with Rh/DuanPhos complex gave the corresponding chiral amine in excellent enantioselectivities (up to 99.7% ee).
通过一种新型的铑/碳催化的酮肟直接氢酰化反应高效地制备了烯酰胺。用这种方法获得了高达88%的烯酰胺分离产率。随后用铑/段氏膦配合物对烯酰胺进行不对称氢化反应，以优异的对映选择性（高达99.7% ee）得到了相应的手性胺。
