Goutzanis Lampros P, Papadogeorgakis Nikolaos, Pavlopoulos Petros M, Petsinis Vasilis, Plochoras Ioannis, Eleftheriadis Efstathios, Pantelidaki Aikaterini, Patsouris Efstratios, Alexandridis Constantinos
Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital of Athens, Dental School, University of Athens, Athens, Greece.
Head Neck. 2009 Mar;31(3):298-307. doi: 10.1002/hed.20959.
Microvessel quantification has been studied extensively as a factor reflecting angiogenesis in various malignant tumors. The aim of our study was to evaluate the vascular fractal dimension and the immunohistochemically positive total vascular area in oral cavity carcinomas in order to assess their potential value as factors reflecting angiogenesis.
Histologic sections from 48 carcinomas and 17 nonmalignant mucosa specimens were evaluated by image analysis using fractal analysis software. Total vascular area was also quantified.
Carcinomas presented higher mean values of vascular fractal dimension and total vascular area compared to normal mucosa. The difference for the vascular fractal dimension was statistically significant.
This study provides evidence that vascular fractal dimension could be used as a reliable factor reflecting angiogenesis in oral squamous cell carcinoma and that there are several statistically significant correlations among total vascular area, vascular fractal dimension, nuclear size, and clinicopathologic factors.
微血管定量分析作为反映各种恶性肿瘤血管生成的一个因素已得到广泛研究。我们研究的目的是评估口腔癌的血管分形维数和免疫组化阳性的总血管面积，以评估它们作为反映血管生成因素的潜在价值。
使用分形分析软件通过图像分析对48例癌组织和17例非恶性黏膜标本的组织学切片进行评估。还对总血管面积进行了定量分析。
与正常黏膜相比，癌组织的血管分形维数和总血管面积的平均值更高。血管分形维数的差异具有统计学意义。
本研究提供了证据，表明血管分形维数可作为反映口腔鳞状细胞癌血管生成的可靠因素，并且总血管面积、血管分形维数、核大小和临床病理因素之间存在若干具有统计学意义的相关性。
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