Landini G, Rippin J W
School of Dentistry, University of Birmingham, U.K.
J Pathol. 1996 Jun;179(2):210-7. doi: 10.1002/(SICI)1096-9896(199606)179:2<210::AID-PATH560>3.0.CO;2-T.
Quantification of the local complexity of the epithelial-connective tissue interface (ECTI) in normal mucosa, epithelial dysplasia, and squamous cell carcinoma of the floor of the mouth was investigated by estimating the local connected fractal dimension in tissue profiles from histological sections. The use of certain parameters of the distribution of the local connected fractal dimensions of the ECTI classifies the cases belonging to these three histopathological diagnoses with 85 per cent accuracy by means of linear discriminant analysis. The values of the local fractal dimension were also used to produce colour-coded dimensional images of the ECTI, to highlight locations with higher irregularity that may correlate with locally invasive 'higher-risk' areas.
通过估计组织学切片中组织轮廓的局部连通分形维数，研究了口腔底部正常黏膜、上皮发育异常和鳞状细胞癌中上皮-结缔组织界面（ECTI）的局部复杂性量化。利用ECTI局部连通分形维数分布的某些参数，通过线性判别分析，对属于这三种组织病理学诊断的病例进行分类，准确率达85%。局部分形维数的值还用于生成ECTI的彩色编码维数图像，以突出显示可能与局部侵袭性“高风险”区域相关的更高不规则性的位置。
