Int J Cardiol. 2010 Aug 6;143(1):96-8. doi: 10.1016/j.ijcard.2008.11.169. Epub 2008 Dec 13.
We have previously found that serum level of pigment epithelium-derived factor (PEDF) is increased in proportion to the accumulation of the number of components of metabolic syndrome in general population. However, the link between PEDF and insulin resistance in hypertensive patients remains unclear. We investigated here whether serum PEDF level was associated with insulin resistance in hypertensive patients. Ninety-seven consecutive outpatients with essential hypertension underwent a complete history and physical examination, determination of blood chemistries, including serum PEDF. In multiple regression analyses, BMI, age (inversely) and PEDF were independently correlated with homeostasis model assessment of insulin resistance (HOMA-IR). When age- and sex-adjusted PEDF levels were stratified by HOMA-IR tertiles, a linear and significant trend was observed. These results demonstrated that serum level of PEDF was an independent determinant of HOMA-IR in patients with essential hypertension. PEDF may play a role in insulin resistance in hypertensive patients.
我们之前发现，在一般人群中，血清色素上皮衍生因子（PEDF）水平与代谢综合征成分数量的积累成正比增加。然而，在高血压患者中 PEDF 与胰岛素抵抗之间的联系尚不清楚。我们在此研究了血清 PEDF 水平是否与高血压患者的胰岛素抵抗有关。97 例连续的原发性高血压门诊患者接受了完整的病史和体检，测定了血液化学物质，包括血清 PEDF。在多元回归分析中，BMI、年龄（负相关）和 PEDF 与稳态模型评估的胰岛素抵抗（HOMA-IR）独立相关。当按 HOMA-IR 三分位数分层调整年龄和性别后 PEDF 水平时，观察到线性和显著的趋势。这些结果表明，在原发性高血压患者中，血清 PEDF 水平是 HOMA-IR 的独立决定因素。PEDF 可能在高血压患者的胰岛素抵抗中发挥作用。
