Department of Gastroenterology, Marmara University, School of Medicine, Pendik, 34899 Istanbul, Turkey.
Clin Chim Acta. 2011 Nov 20;412(23-24):2296-9. doi: 10.1016/j.cca.2011.08.025. Epub 2011 Aug 24.
Increased serum concentrations of pigment epithelium-derived factor (PEDF) have been linked to the metabolic syndrome in the general population. However, the relationship between serum PEDF and nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, remains unknown.
We assayed serum PEDF levels in 156 patients with biopsy-proven NAFLD and 103 nonsteatotic control subjects who were matched for age and sex. The association between levels of PEDF and clinical, biochemical, and histological phenotypes was examined.
NAFLD patients had significantly higher serum PEDF levels (1.97±0.50 μg/mL) than control subjects (1.51±0.49 μg/mL, Student's t test, P<0.001). Multivariable-adjusted stepwise regression analysis showed that PEDF ([beta]=0.32, t=3.13, P=0.002) and triglycerides ([beta]=0.22, t=2.23, P=0.02) were, in the order they entered into the model, the main independent predictors of steatosis scores in our patients with NAFLD.
Serum PEDF levels are significantly increased in patients with biopsy-proven NAFLD and are associated with liver steatosis independently of traditional risk factors.
在普通人群中，血清色素上皮衍生因子（PEDF）浓度的增加与代谢综合征有关。然而，血清 PEDF 与非酒精性脂肪性肝病（NAFLD）之间的关系，即代谢综合征的肝脏表现，尚不清楚。
我们检测了 156 例经活检证实的 NAFLD 患者和 103 例年龄和性别相匹配的非脂肪性肝病对照者的血清 PEDF 水平。研究了 PEDF 水平与临床、生化和组织学表型之间的关系。
NAFLD 患者的血清 PEDF 水平（1.97±0.50 μg/mL）明显高于对照组（1.51±0.49 μg/mL，Student's t 检验，P<0.001）。多变量逐步回归分析显示，PEDF（[beta]=0.32，t=3.13，P=0.002）和甘油三酯（[beta]=0.22，t=2.23，P=0.02）是进入模型的顺序，是我们的 NAFLD 患者肝脂肪变性评分的主要独立预测因子。
经活检证实的 NAFLD 患者的血清 PEDF 水平显著升高，与传统危险因素无关，与肝脂肪变性有关。
