Frey U H, Michalsen A, Merse S, Dobos G J, Siffert W
Institut für Pharmakogenetik, Universitätsklinikum, Essen, Germany.
Eur J Med Res. 2008 Dec 3;13(12):576-8.
In mice, heterozygous knockout of the stimulatory G protein Gas results in obesity which suggests a key role of Gas in body weight regulation. We have recently identified a functional G(-1211)A promoter polymorphism in the human GNAS gene encoding Gas, the GG genotype being associated with increased promoter activity and lipolysis in vitro and increased weight loss capacity in vivo. The present study aimed to independently confirm these results. We genotyped 87 subjects who underwent a 7-day modified fast for the GNAS polymorphism and recorded weight, hunger, and mood. While both mood and hunger were not dependent on genotype, GNAS genotypes were significantly associated with weight loss (GG: -5.0 +/- 1.5 kg, n = 28; AG: -4.2 +/- 1.1 kg, n = 50; AA: -3.2 +/- 1.2, n = 9; p = 0.0003). The present study reconfirms our earlier reported findings and suggests that GNAS genotypes also influence weight loss during short-term fasting. related to a low vascular density (CD31 expression) in CDC.
在小鼠中，刺激性G蛋白Gas的杂合敲除会导致肥胖，这表明Gas在体重调节中起关键作用。我们最近在编码Gas的人类GNAS基因中鉴定出一种功能性G（-1211）A启动子多态性，GG基因型与体外启动子活性增加、脂肪分解增加以及体内体重减轻能力增强有关。本研究旨在独立证实这些结果。我们对87名接受为期7天改良禁食的受试者进行了GNAS多态性基因分型，并记录了体重、饥饿感和情绪。虽然情绪和饥饿感均不依赖于基因型，但GNAS基因型与体重减轻显著相关（GG：-5.0±1.5千克，n = 28；AG：-4.2±1.1千克，n = 50；AA：-3.2±1.2，n = 9；p = 0.0003）。本研究再次证实了我们先前报道的结果，并表明GNAS基因型在短期禁食期间也会影响体重减轻。与CDC中低血管密度（CD31表达）有关。
