Odendaal H J, Tribe R, Kriel C J, Meyer M, Thom J C
Department of Obstetrics and Gynaecology, Tygerberg Hospital, South Africa.
Vox Sang. 1991;60(3):169-73. doi: 10.1111/j.1423-0410.1991.tb00897.x.
Nine patients with severe Rh iso-immunization were treated by plasma exchange combined with immunosuppression. Apart from 3 abortions, previous pregnancy losses consisted of 7 intra-uterine and 5 neonatal deaths. Only 2 patients had had no previous pregnancy loss. Differences in the optical density of the amniotic fluid of 8 patients fell into the upper Liley zone. There was one intra-uterine death due to abruptio placentae but no neonatal deaths. When the outcome of the pregnancy immediately preceding the treatment pregnancy was compared to the treatment pregnancy, the fetal loss was reduced from 6 to 1. No adverse fetal effects were encountered.
9例严重Rh血型免疫患者接受了血浆置换联合免疫抑制治疗。除3例流产外，既往妊娠丢失包括7例宫内死亡和5例新生儿死亡。只有2例患者既往无妊娠丢失。8例患者羊水光密度差异落入Liley区上部。有1例因胎盘早剥导致的宫内死亡，但无新生儿死亡。将治疗前紧邻的妊娠结局与本次治疗妊娠的结局进行比较时，胎儿丢失率从6例降至1例。未发现对胎儿有不良影响。
