Odendaal H J, King J B, Oosthuizen O J
S Afr Med J. 1986 Jan 18;69(2):122-4.
Two patients are described in whom previous fetal loss had occurred due to rhesus (Rh) disease. In both patients apheresis was performed from a gestational age of 25 weeks in an attempt to remove excessive antibodies. In addition, production of new antibodies was suppressed by the administration of prednisone and azathioprine. A reduction in the antibody titres was accomplished although this was not reflected by a marked decrease in amniotic fluid bilirubin levels. The patients were delivered at gestational ages of 32 and 33 weeks since fetal lung maturity had then been demonstrated. Both babies were surprisingly little affected by the Rh disease and only one exchange transfusion was necessary for each. Neonatal follow-up for 2 years and 1 year respectively revealed no fetal abnormalities.
本文描述了两名因恒河猴（Rh）疾病导致先前胎儿丢失的患者。在这两名患者中，从孕25周开始进行血液成分单采术，试图去除过多的抗体。此外，通过给予泼尼松和硫唑嘌呤来抑制新抗体的产生。尽管羊水胆红素水平没有显著下降，但抗体滴度有所降低。由于当时已证明胎儿肺成熟，两名患者分别在孕32周和33周分娩。两个婴儿受Rh疾病的影响出人意料地小，每个婴儿仅需进行一次换血输血。分别对两名婴儿进行2年和1年的新生儿随访，未发现胎儿异常。
