Li M H, Holtås S
Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Acta Radiol. 1991 Jul;32(4):279-85.
The MR findings in 7 patients with neurofibromatosis involving the spine were evaluated. Six patients had paraspinal tumors at multiple levels. In 4 they were bilateral. Five patients had multiple intraspinal lesions, frequently with growth through the neural foramen. In one patient paraspinal tumors were found in the lumbar sacral plexus and in another bony dysplasia and meningoceles but no tumors were disclosed. In 2 patients the lesions were associated with bilateral acoustic neuromas and multiple intracranial meningeomas. In one of these a spinal meningeoma with signal characteristics close to spinal cord was found. The other tumors had a signal that was equal to or slightly lower than the spinal cord and slightly higher than muscle on T1-weighted images. On T2-weighted images the tumors had a markedly increased signal compared to surrounding tissue. In 3 patients with tumors larger than 4 cm the signal intensity was inhomogeneous with decreased signal in the center on T2-weighted images, indicating the presence of increased fibrous tissue. Gadolinium-DTPA was given to one patient with marked increase in intensity of small tumors on T1-weighted images. The study shows that MR imaging is the modality of choice for evaluating most aspects of spinal and paraspinal neurofibromatosis.
对7例累及脊柱的神经纤维瘤病患者的磁共振成像（MR）表现进行了评估。6例患者在多个节段出现椎旁肿瘤。其中4例为双侧性。5例患者有多个脊髓内病变，常通过神经孔生长。1例患者在腰骶丛发现椎旁肿瘤，另1例有骨发育异常和脊膜膨出，但未发现肿瘤。2例患者的病变与双侧听神经瘤和多发颅内脑膜瘤相关。其中1例发现1个信号特征接近脊髓的脊髓脑膜瘤。其他肿瘤在T1加权图像上的信号等于或略低于脊髓，略高于肌肉。在T2加权图像上，肿瘤信号与周围组织相比明显增高。3例肿瘤大于4 cm的患者，T2加权图像上信号强度不均匀，中心信号减低，提示纤维组织增多。1例患者给予钆喷酸葡胺后，T1加权图像上小肿瘤信号强度明显增加。该研究表明，MR成像是评估脊柱和椎旁神经纤维瘤病大多数方面的首选检查方法。
