喉癌患者的血浆同型半胱氨酸、叶酸和维生素B12水平

Plasma homocysteine, folate, and vitamin B12 levels in patients with laryngeal cancer.

作者信息

Nacci Andrea, Dallan Iacopo, Bruschini Luca, Traino Antonio Claudio, Panicucci Erica, Bruschini Paolo, Mancini Valentina, Rognini Ferdinando, Fattori Bruno

机构信息

Third Otorhinolaryngology Unit, Department of Neurosciences, University of Pisa, Via Savi No. 10, 56126 Pisa, Italy.

出版信息

Arch Otolaryngol Head Neck Surg. 2008 Dec;134(12):1328-33. doi: 10.1001/archotol.134.12.1328.

DOI:10.1001/archotol.134.12.1328

PMID:19075131

Abstract

OBJECTIVE

To determine plasma levels of homocysteine, folate, and vitamin B12 in patients with laryngeal cancer and a control group.

DESIGN

Analysis of homocysteine, folate, and vitamin B12 levels in 25 consecutive untreated patients with laryngeal carcinoma and 80 healthy control participants. The study and control groups were subdivided into smokers, ex-smokers, and nonsmokers, as well as drinkers and nondrinkers.

INTERVENTION

The AxSYM system was used to measure total homocysteine levels, and the ARCHITECT system (both Abbott-Diagnostics Division) was used to measure folate and vitamin B12 levels.

MAIN OUTCOME MEASURES

Homocysteine, folate, and vitamin B12 levels.

RESULTS

The mean (SD) level of total homocysteine in patients with laryngeal carcinoma was 2.84 (1.62) mg/L vs 0.99 (0.24) mg/L in the control group (P <.001). The mean (SD) folate plasma level was 4.3 (2.2) ng/mL vs 7.9 (2.4) ng/mL (P <.001).

CONCLUSIONS

Metabolic alterations in homocysteine, folate, and vitamin B12 levels, especially hypofolatemia, could be associated with laryngeal cancer. Lengthier follow-up studies and larger groups of patients will help determine the real role of these metabolic alterations.

摘要