Shukla Vivek, Coumoul Xavier, Vassilopoulos Athanassios, Deng Chu-Xia
Genetics of Development and Disease Branch, 10/9N105, Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Mol Med. 2008 Dec;8(8):727-40. doi: 10.2174/156652408786733694.
Hereditary breast cancers affect women who have an increased risk of developing tumors because of a familial history. In most cases, they can be attributed to mutations in the breast cancer associated gene 1 and 2 (BRCA1 and BRCA2). Recent studies have demonstrated a link between the insulin-like growth factor (IGF) signaling pathway and familial breast cancer incidence. IGF and IGF receptors represent a family of biological growth factors and transducers, which have been involved in both physiological and pathological processes. It has been shown that BRCA1 regulates expression of several members of the IGF family. Here, we will examine our understanding of the functions of IGF/IGF-receptor signaling, the development of new inhibitors of this pathway and the related mechanisms of familial breast cancer formation.
遗传性乳腺癌影响那些因家族病史而患肿瘤风险增加的女性。在大多数情况下，它们可归因于乳腺癌相关基因1和2（BRCA1和BRCA2）的突变。最近的研究表明胰岛素样生长因子（IGF）信号通路与家族性乳腺癌发病率之间存在联系。IGF和IGF受体代表一类生物生长因子和转导分子，它们参与了生理和病理过程。研究表明BRCA1调节IGF家族多个成员的表达。在此，我们将探讨我们对IGF/IGF受体信号功能的理解、该通路新抑制剂的研发以及家族性乳腺癌形成的相关机制。
