Nounou Mohamed I, El-Khordagui Labiba K, Khalafallah Nawal A, Khalil Said A
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77030, USA.
Recent Pat Drug Deliv Formul. 2008;2(1):9-18. doi: 10.2174/187221108783331375.
Although the formulation of effective topical drug delivery system is one of the most sophisticated pharmaceutical preparations, it has attracted researchers due to many medical advantages associated with it. Topical drug delivery systems can act superficially on skin surface, locally in dermal layer of the skin or transdermally to provide successful delivery of drug molecules to the systemic circulation avoiding the traditional problems and limitations of conventional routes of drug delivery. Many novel formulations have been utilized topically to enhance either permeability or drug targeting to a specific layer of the skin such as Liposomes, ethosomes, transfersomes, niosomes and catezomes. The main problem with all of these formulations is that there is no distinct barrier between the targeting and localization action to a certain layer of the skin and the transdermal action to the circulation of these preparations. Any minimal change in the formulation could transform it from a local targeting preparation to a systemic one. This article deals with the innovations pertaining to the use of various types of liposomal preparations and liposomal like preparations for topical drug delivery and the patents associated with it.
尽管有效的局部给药系统的制剂是最复杂的药物制剂之一，但由于与之相关的许多医学优势，它吸引了研究人员。局部给药系统可以作用于皮肤表面、皮肤真皮层局部或经皮给药，以成功地将药物分子递送至体循环，避免传统给药途径的问题和局限性。许多新型制剂已被局部用于增强渗透性或使药物靶向皮肤的特定层，如脂质体、醇质体、传递体、非离子表面活性剂泡囊和立方液晶囊泡。所有这些制剂的主要问题是，在这些制剂靶向和定位于皮肤某一层的作用与经皮进入循环的作用之间没有明显的屏障。制剂的任何微小变化都可能使其从局部靶向制剂转变为全身制剂。本文探讨了与各种类型脂质体制剂和类脂质体制剂用于局部给药相关的创新及其相关专利。
