Español T, Garcia X, Caragol I, Sauleda S, Muntane C
Pediatric Hospital R.S. Valle Hebron, Barcelona, Spain.
Immunol Invest. 1991 Apr;20(2):215-21. doi: 10.3109/08820139109050790.
HIV infection of a fetus from an infected mother has severe immunological implications because it destroys still immature immune system. The abnormalities observed are precocious in the infants. When the infection occurs in perinatal period, clinical and immunological manifestations can present themselves at the age of 2-5 years. Two patterns of HIV infection can be distinguished. Humoral immunodeficiency is present in a high proportion of patients and leads to repeated bacterial infections and progression of the disease. Immunoglobulin substitution therapy improves clinical manifestations and can help to avoid viral replication.
受感染母亲的胎儿感染艾滋病毒会产生严重的免疫学影响，因为它会破坏仍未成熟的免疫系统。在婴儿中观察到的异常情况出现得较早。当感染发生在围产期时，临床和免疫学表现可能在2至5岁时出现。艾滋病毒感染可分为两种类型。高比例患者存在体液免疫缺陷，会导致反复细菌感染和疾病进展。免疫球蛋白替代疗法可改善临床表现，并有助于避免病毒复制。
