Pino-Lagos Karina, Benson Micah J, Noelle Randolph J
Department of Microbiology and Immunology, Dartmouth College, Dartmouth Medical School, Lebanon, NH 03756, USA.
Ann N Y Acad Sci. 2008 Nov;1143:170-87. doi: 10.1196/annals.1443.017.
On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T(reg)) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of T(reg) function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of T(reg). Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on T(reg). Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. Now these findings can be interpreted in light of the revelations that RA controls leukocyte homing and T(reg) function.
偶尔，新兴的科学领域相互交叉，从而产生重大发现。在过去十年中，免疫领域中调节性T细胞（T(reg)）的发现彻底改变了我们对免疫系统如何被控制的理解。与T(reg)功能这一迅速兴起的领域相交的是，视黄酸（RA）控制T(reg)的归巢和分化这一发现。立刻，关于RA作用的分子基础、其受体以及它如何控制细胞分化的丰富而广泛的知识能够且将会被用于理解其对T(reg)的深远影响。从历史上看，维生素A缺乏与补充以及RA激动剂已被证明会深刻影响免疫。现在，这些发现可以根据RA控制白细胞归巢和T(reg)功能这一揭示来进行解读。
