Rudkowski R, Graham G G, Ziegler J B, Champion G D
Prince of Wales Children's Hospital, Randwick, NSW, Australia.
J Rheumatol. 1991 May;18(5):666-71.
The antirheumatic drug, sodium aurothiomalate (GSTM), is not a well defined substance and chemical changes occur in the heat sterilization of the commercial ampoules (Myocrisin). In a comparison of the pharmacological properties of Myocrisin with freshly prepared solutions of GSTM, their effects on the chemiluminescence of polymorphonuclear leukocytes (PMN) activated by phorbol myristate acetate (PMA) were studied. Chemiluminescence was measured in the presence of GSTM from solid material and from Myocrisin ampoules. Myocrisin from 1 and 5 mg ampoules and GSTM in fresh solutions heated at 95 degrees C for 30 min inhibited chemiluminescence, whereas Myocrisin from the higher strength (10-50 mg) ampoules and GSTM in unheated solutions showed no effect at low concentrations and enhancement of chemiluminescence at higher concentrations. Since the gold complexes present in the different strength Myocrisin ampoules do not have identical biological effects, the use of GSTM in investigational studies should involve consideration of its source.
抗风湿药物硫代苹果酸金钠（GSTM）并非一种明确界定的物质，且市售安瓿制剂（米诺索明）在热灭菌过程中会发生化学变化。在比较米诺索明与新制备的GSTM溶液的药理特性时，研究了它们对佛波醇肉豆蔻酸酯乙酸盐（PMA）激活的多形核白细胞（PMN）化学发光的影响。在有固体材料中的GSTM以及米诺索明安瓿制剂存在的情况下测量化学发光。来自1毫克和5毫克安瓿的米诺索明以及在95摄氏度加热30分钟的新鲜溶液中的GSTM抑制化学发光，而来自更高强度（10 - 50毫克）安瓿的米诺索明以及未加热溶液中的GSTM在低浓度时无作用，在高浓度时增强化学发光。由于不同强度米诺索明安瓿中存在的金络合物不具有相同的生物学效应，因此在研究中使用GSTM时应考虑其来源。
