金诺芬和硫代苹果酸金钠对类风湿关节炎患者受刺激的滑膜组织细胞化学发光反应的影响。
The effects of auranofin and gold sodium aurothiomalate on the chemiluminescent response of stimulated synovial tissue cells from patients with rheumatoid arthritis.
作者信息
Harth M, McCain G A, Orange J F
出版信息
J Rheumatol. 1985 Oct;12(5):881-4.
PMID:3936929
Abstract
Mononuclear cells were obtained from synovial tissue of patients with rheumatoid arthritis. The cells were stimulated with opsonized zymosan and generation of reactive oxygen species (ROS) was assayed by chemiluminescence. The effects of gold sodium thiomalate (GSTM) and auranofin (AF) on the chemiluminescent response were observed. Synovial tissue cells showed a chemiluminescent response suggesting their ability to release ROS; this response was inhibited by AF but not by GSTM.
摘要
从类风湿性关节炎患者的滑膜组织中获取单核细胞。用调理酵母聚糖刺激这些细胞，并通过化学发光法测定活性氧（ROS）的生成。观察了硫代苹果酸金钠（GSTM）和金诺芬（AF）对化学发光反应的影响。滑膜组织细胞表现出化学发光反应，表明它们具有释放ROS的能力；这种反应被AF抑制，但未被GSTM抑制。
相似文献
1
2
Monocyte dependent excited oxygen radical generation in rheumatoid arthritis: inhibition by gold sodium thiomalate.
J Rheumatol. 1983 Oct;10(5):701-7.
3
Prevalence of eosinophilia during gold therapy for rheumatoid arthritis.
J Rheumatol. 1983 Feb;10(1):121-3.
4
Auranofin and sodium aurothiomalate in the treatment of rheumatoid arthritis. A double-blind, comparative multicenter study.金诺芬和硫代苹果酸金钠治疗类风湿性关节炎。一项双盲、对比性多中心研究。
J Rheumatol Suppl. 1982 Jul-Aug;8:184-9.
5
One-year comparative study of gold sodium thiomalate and auranofin in the treatment of rheumatoid arthritis.硫代苹果酸金钠与金诺芬治疗类风湿关节炎的一年期对比研究。
J Rheumatol. 1985 Feb;12(1):60-7.
6
7
8
[Auranofin and sodium aurothiomalate: a comparative review. I. Physicochemical, pharmacokinetic and pharmacological properties].[金诺芬与硫代苹果酸金钠：比较性综述。I. 物理化学、药代动力学及药理学特性]
Med Clin (Barc). 1985 May 25;84(20):834-9.
9
引用本文的文献
1
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.代谢相关基因 TXNRD1 通过 Nrf2/HO-1 通路调控小气道上皮细胞中香烟烟雾诱导的炎症和氧化应激。
Oxid Med Cell Longev. 2022 Dec 19;2022:7067623. doi: 10.1155/2022/7067623. eCollection 2022.
Zotero 插件