Department of Radiological Technology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
J Nucl Cardiol. 2017 Aug;24(4):1378-1388. doi: 10.1007/s12350-016-0518-z. Epub 2016 May 19.
We compared two reconstruction algorisms and two cardiac functional evaluation software programs in terms of their accuracy for estimating ejection fraction (EF) of small hearts (SH).
The study group consisted of 66 pediatric patients. Data were reconstructed using a filtered back projection (FBP) method without the resolution correction (RC) and an iterative method based on an ordered subset expectation maximization (OSEM) algorithm with the RC. EF was evaluated using two software programs of quantitative gated single-photon emission computed tomography (SPECT) (QGS) and cardioREPO. We compared the EF of gated myocardial perfusion SPECT to echocardiographic measurement (Echo).
Forty-eight of 66 patients had an end-systolic volume < 20 mL which was used as the criterion for being included in the SH group, and the SH effect led to an overestimation of EF. While significant differences were observed between Echo (66.9 ± 5.0%) and QGS-FBP without RC (76.9 ± 8.4%, P < .0001), QGS-OSEM with RC (76.6 ± 8.6%, P < .0001), and cardioREPO-FBP without RC (72.1 ± 10.0%, P = .0011), no significant difference was observed between Echo and cardioREPO-OSEM with RC (67.4 ± 6.1%) in SH group.
In pediatric gated myocardial perfusion SPECT, the SH effect can be significantly reduced when an OSEM algorithm is used with RC in combination with the specific cardioREPO algorithm.
我们比较了两种重建算法和两种心脏功能评估软件程序，以评估它们在估计小心脏（SH）射血分数（EF）方面的准确性。
研究组包括 66 名儿科患者。数据使用滤波反投影（FBP）方法重建，不进行分辨率校正（RC），以及基于有序子集期望最大化（OSEM）算法的迭代方法，并进行 RC。使用两种定量门控单光子发射计算机断层扫描（SPECT）（QGS）和 cardioREPO 的软件程序评估 EF。我们比较了门控心肌灌注 SPECT 的 EF 与超声心动图测量（Echo）。
66 例患者中有 48 例的收缩末期容积 < 20 毫升，作为纳入 SH 组的标准，SH 效应导致 EF 高估。虽然 Echo（66.9 ± 5.0%）与 QGS-FBP 无 RC（76.9 ± 8.4%，P <.0001）、QGS-OSEM 与 RC（76.6 ± 8.6%，P <.0001）和 cardioREPO-FBP 无 RC（72.1 ± 10.0%，P =.0011）之间存在显著差异，但在 SH 组中，Echo 与 cardioREPO-OSEM 与 RC（67.4 ± 6.1%）之间无显著差异。
在儿科门控心肌灌注 SPECT 中，当 OSEM 算法与 RC 结合使用特定的 cardioREPO 算法时，SH 效应可以显著降低。
