胞壁酰肽对线粒体呼吸的影响。
Effect of muramyl peptides on mitochondrial respiration.
作者信息
El-Jamal N, Bahr G M, Echtay K S
机构信息
Faculty of Medicine and Medical Sciences and Faculty of Sciences, University of Balamand, Tripoli, Lebanon.
出版信息
Clin Exp Immunol. 2009 Jan;155(1):72-8. doi: 10.1111/j.1365-2249.2008.03794.x.
Muramyl peptides have been shown to exert several biological activities including potentiation of humoral and cell-mediated immunity and stimulation of natural resistance. The mode of action of muramyl peptides has not been elucidated fully and the immunological activities of some derivatives have been associated with toxic effects, including pyrogenicity and inflammatory reactions. Nevertheless, the impact of muramyl peptides on mitochondrial respiration has never been addressed. In this study, the in vitro effects of muramyl peptides on rat liver mitochondria were examined. Toxic muramyl peptides induced a significant decrease in respiratory control ratio versus non-toxic analogues. These results were confirmed by in vivo studies in mice and were extended to mitochondria isolated from spleens. Our data address, for the first time, the effect of muramyl peptides on mitochondrial bioenergetics. Further studies are required to reveal the mechanism of mitochondrial toxicity in relation to the damaging effects of toxic muramyl peptides.
已证明胞壁酰肽具有多种生物活性，包括增强体液免疫和细胞介导的免疫以及刺激天然抵抗力。胞壁酰肽的作用方式尚未完全阐明，一些衍生物的免疫活性与毒性作用有关，包括致热原性和炎症反应。然而，胞壁酰肽对线粒体呼吸的影响从未得到研究。在本研究中，检测了胞壁酰肽对大鼠肝脏线粒体的体外作用。与无毒类似物相比，有毒胞壁酰肽导致呼吸控制率显著降低。这些结果在小鼠体内研究中得到证实，并扩展到从脾脏分离的线粒体。我们的数据首次揭示了胞壁酰肽对线粒体生物能量学的影响。需要进一步研究以揭示与有毒胞壁酰肽的破坏作用相关的线粒体毒性机制。
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