胞壁酰肽对年轻和老年小鼠免疫系统细胞免疫调节特性的比较研究
Comparative study of immunomodulatory properties of muramyl peptides on immune system cells of young and old mice.
作者信息
Dozmorov I M, Kuzin I I, Lutsan N I, Lutsenko G V, Prokhorova A L, Sapozhnikov A M, Andronova T M, Ivanov V T
机构信息
Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
出版信息
Immunopharmacol Immunotoxicol. 1994 May;16(2):149-63. doi: 10.3109/08923979409007087.
The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.
比较了两种合成的胞壁酰肽（MP）：胞壁酰二肽和葡糖胺酰胞壁酰二肽的免疫调节作用。结果表明，MP对免疫反应的影响是T淋巴细胞调节因子平衡改变的结果。MP对老年小鼠免疫反应和淋巴细胞功能的作用仅具有刺激作用：增加T辅助前体细胞频率以及巨噬细胞产生白细胞介素-1。在后者中，两种MP均起到校正作用，将老年小鼠巨噬细胞中降低的白细胞介素-1产生恢复到年轻对照水平。
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