Malaĭtsev V V, Bogdanov I M, Sukhikh G T, Andronova T M
Biull Eksp Biol Med. 1985 Aug;100(8):221-3.
Muramyl dipeptide and its synthetic derivative N-acetyl-glucosaminyl-N-acetyl-muramyl-alanyl - D-isoglutamine induce mitogenic factor production for Con A activated blasts (Con A-blasts) in splenocytes. The maximal factor production was revealed 24 h after stimulation with muramyl dipeptide or its derivative. Addition of the inducers to the culture of Con A-blasts led but to the negligible proliferative response. Therefore, the mitogenic action of muramyl dipeptide on target cells is mediated by the growth factor, evidently by interleukin-2. It has been also shown that muramyl dipeptide and its derivative with Con A exerted a synergic action in interleukin-2 induction.
胞壁酰二肽及其合成衍生物N-乙酰葡糖胺基-N-乙酰胞壁酰丙氨酰-D-异谷氨酰胺可诱导脾细胞中伴刀豆球蛋白A激活的母细胞（Con A-母细胞）产生促有丝分裂因子。在用胞壁酰二肽或其衍生物刺激后24小时，促有丝分裂因子产量达到最高。将诱导剂添加到Con A-母细胞培养物中，只会导致可忽略不计的增殖反应。因此，胞壁酰二肽对靶细胞的促有丝分裂作用是由生长因子介导的，显然是由白细胞介素-2介导的。研究还表明，胞壁酰二肽及其衍生物与Con A在诱导白细胞介素-2方面发挥协同作用。
Zotero 插件