Suga M, Ando M, Nishikawa H, Araki S
First Department of Internal Medicine, Kumamoto University School, Japan.
Jpn J Med. 1991 Mar-Apr;30(2):108-12. doi: 10.2169/internalmedicine1962.30.108.
Adenosine deaminase (ADA) activity and free interleukin (IL)-2 receptor levels were assayed in serum samples from patients with mycoplasma and bacterial pneumonia to evaluate the usefulness of these parameters in distinguishing between these diseases at an early stage. Serum ADA and free IL-2 receptor levels in patients with mycoplasma pneumonia (32.4 +/- 9.2 U/l, 960 +/- 204 U/ml) were significantly higher than those in patients with bacterial pneumonia (12.5 +/- 3.3 U/l, 425 +/- 86 U/ml) and in healthy controls (14.0 +/- 3.4 U/l, 286 +/- 49 U/ml) (p less than 0.001). Of the 20 mycoplasma pneumonia cases, 19 showed increased levels of ADA over 20.8 U/l; in 17 of the 19, the increase of ADA was seen before the elevation of the specific antibody to Mycoplasma pneumoniae. In contrast, serum ADA levels in all 20 cases of bacterial pneumonia were lower than 20.8 U/l. There results indicate that assays for serum ADA and free IL-2 receptor levels are useful in distinguishing between bacterial and mycoplasma pneumonia at an early stage.
检测支原体肺炎和细菌性肺炎患者血清样本中的腺苷脱氨酶（ADA）活性及游离白细胞介素（IL）-2受体水平，以评估这些指标在早期区分这两种疾病中的作用。支原体肺炎患者血清ADA和游离IL-2受体水平（分别为32.4±9.2 U/l、960±204 U/ml）显著高于细菌性肺炎患者（分别为12.5±3.3 U/l、425±86 U/ml）及健康对照者（分别为14.0±3.4 U/l、286±49 U/ml）（p＜0.001）。20例支原体肺炎病例中，19例ADA水平高于20.8 U/l；在这19例中的17例，ADA升高出现在肺炎支原体特异性抗体升高之前。相比之下，20例细菌性肺炎病例的血清ADA水平均低于20.8 U/l。这些结果表明，检测血清ADA和游离IL-2受体水平有助于早期区分细菌性肺炎和支原体肺炎。
