Okuno Tomoko, Ueda Mikiko, Tsuruyama Tatsuaki, Haga Hironori, Takada Yasutsugu, Maetani Yoji, Tamaki Keiji, Manabe Toshiaki, Tanaka Koichi, Uemoto Shinji
Laboratory of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
Cancer Sci. 2009 Mar;100(3):520-8. doi: 10.1111/j.1349-7006.2008.01056.x. Epub 2008 Dec 11.
We performed loss of heterozygosity (LOH) analysis on five chromosomal arms (1p, 3p, 9p, 10q, 17p) in hepatocellular carcinoma (HCC). Univariate analyses of 80 patients who underwent liver transplantation demonstrated significant correlations between cancer recurrence and the following variables: LOH on 3p26, LOH on 10q23, LOH on 17p13, tumor diameter > or = 5 cm, number of tumors > or = 4, histologic Grade 3, alpha-fetoprotein (AFP) > or = 400 ng/mL, American Joint Committee on Cancer (AJCC) pT classification, and portal invasion. Patients with LOH on 10q23 exhibited a significantly higher 3-year recurrence rate (38.9%vs 11.9%, P = 0.0009). Multivariate analysis identified LOH on 10q23, histologic Grade 3, tumor nodules > or = 4, and AFP > or = 400 ng/mL as the risk factors of advanced HCC recurrence. These results suggest that LOH on 10q23 is associated with metastatic recurrence of HCC.
我们对肝细胞癌（HCC）的五条染色体臂（1p、3p、9p、10q、17p）进行了杂合性缺失（LOH）分析。对80例行肝移植的患者进行单因素分析，结果显示癌症复发与以下变量之间存在显著相关性：3p26处的LOH、10q23处的LOH、17p13处的LOH、肿瘤直径≥5 cm、肿瘤数量≥4个、组织学3级、甲胎蛋白（AFP）≥400 ng/mL、美国癌症联合委员会（AJCC）pT分类以及门静脉侵犯。10q23处存在LOH的患者3年复发率显著更高（38.9%对11.9%，P = 0.0009）。多因素分析确定10q23处的LOH、组织学3级、肿瘤结节≥4个以及AFP≥400 ng/mL为晚期HCC复发的危险因素。这些结果表明，10q23处的LOH与HCC的转移复发相关。
