ZDHHC2在人类肝细胞癌转移和复发中的关键作用。
A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.
作者信息
Peng Chuanhui, Zhang Zhijun, Wu Jian, Lv Zhen, Tang Jie, Xie Haiyang, Zhou Lin, Zheng Shusen
机构信息
Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, China.
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
出版信息
Biomed Res Int. 2014;2014:832712. doi: 10.1155/2014/832712. Epub 2014 Jun 9.
It has been demonstrated that loss of heterozygosity (LOH) was frequently observed on chromosomes 8p22-p23 in hepatocellular carcinoma (HCC) and was associated with metastasis and prognosis of HCC. However, putative genes functioning on this chromosomal region remain unknown. In this study, we evaluated LOH status of four genes on 8p22-p23 (MCPH1, TUSC3, KIAA1456, and ZDHHC2). LOH on ZDHHC2 was associated with early metastatic recurrence of HCC following liver transplantation and was correlated with tumor size and portal vein tumor thrombi. Furthermore, our results indicate that ZDHHC2 expression was frequently decreased in HCC. Overexpression of ZDHHC2 could inhibit proliferation, migration, and invasion of HCC cell line Bel-7402 in vitro. These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC.
研究表明，在肝细胞癌（HCC）中，8号染色体p22 - p23区域经常出现杂合性缺失（LOH），且与HCC的转移和预后相关。然而，在该染色体区域发挥作用的假定基因仍不清楚。在本研究中，我们评估了8p22 - p23区域四个基因（MCPH1、TUSC3、KIAA1456和ZDHHC2）的LOH状态。ZDHHC2基因的杂合性缺失与肝移植后HCC的早期转移复发相关，并与肿瘤大小和门静脉癌栓相关。此外，我们的结果表明，ZDHHC2在HCC中表达经常降低。ZDHHC2的过表达在体外可抑制HCC细胞系Bel - 7402的增殖、迁移和侵袭。这些结果表明ZDHHC2作为一种肿瘤抑制因子在HCC转移和复发中起重要作用。
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