Altinel Mert, Arpali Emre, Turhan Nesrin, Gonenc Faruk, Yazicioglu Ahmet
Department of Urology, Turkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
Urol Int. 2008;81(4):452-5. doi: 10.1159/000167846. Epub 2008 Dec 10.
CD44 is thought to play an important role in the tumorigenesis of renal cell carcinoma (RCC). We retrospectively evaluated the expression of CD44s by immunohistochemical analysis in conventional RCC patients and in conventional RCC patients with renal vein or vena cava thrombus and investigated the differences in the pattern of expression of CD44s between the two groups.
Thirty RCC specimens and four RCC specimens with renal vein and five RCC specimens with vena cava thrombus were analyzed immunohistochemically using a CD44s-specific antibody. The expression of CD44s in RCC with renal vein or vena cava thrombus was compared with the expression of CD44s in RCC without renal vein or vena cava extention.
Of the 30 tumor specimens without thrombus, 16 (53%) expressed CD44s. Staining was also positive in all of the nine specimens with thrombus. CD44s expression was weak in the tumour specimens without thrombus. RCC specimens with renal vein or vena cava thrombus exhibited strong positive staining for CD44s.
The increased expression of CD44s seems to be correlated with tumor thrombus formation in renal vein or vena cava. CD44s may play a role in the formation of renal vein or vena cava extention.
CD44被认为在肾细胞癌（RCC）的肿瘤发生过程中起重要作用。我们通过免疫组织化学分析回顾性评估了CD44s在传统RCC患者以及伴有肾静脉或腔静脉血栓的传统RCC患者中的表达情况，并研究了两组之间CD44s表达模式的差异。
使用CD44s特异性抗体对30例RCC标本、4例伴有肾静脉血栓的RCC标本和5例伴有腔静脉血栓的RCC标本进行免疫组织化学分析。将伴有肾静脉或腔静脉血栓的RCC中CD44s的表达与无肾静脉或腔静脉扩展的RCC中CD44s的表达进行比较。
在30例无血栓的肿瘤标本中，16例（53%）表达CD44s。在所有9例有血栓的标本中染色也呈阳性。无血栓的肿瘤标本中CD44s表达较弱。伴有肾静脉或腔静脉血栓的RCC标本对CD44s呈强阳性染色。
CD44s表达增加似乎与肾静脉或腔静脉中的肿瘤血栓形成相关。CD44s可能在肾静脉或腔静脉扩展的形成中起作用。
