Katzberg Hans D, Bril Vera
From the Division of Neurology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada.
J Clin Neuromuscul Dis. 2005 Mar;6(3):109-13. doi: 10.1097/01.cnd.0000155026.66153.f0.
: We aimed to determine whether the diagnostic yield of single-fiber electromyography (SFEMG) in different grades of ocular myasthenia gravis (OMG) is enhanced by repetitive nerve stimulation studies (RNS).
: One hundred twenty-one patients with a diagnosis of mild, moderate, or severe OMG based on clinical criteria had SFEMG of the frontalis muscle and RNS of the facial nerve. Tests results were compared by contingency table analysis.
: In these patients, 19% had abnormal RNS and 95% had abnormal SFEMG. SFEMG was abnormal in 93%, 96%, and 100% with mild, moderate, and severe OMG, respectively. One patient with abnormal RNS had normal SFEMG, but the SFEMG study was incomplete.
: Like in generalized MG, SFEMG is more sensitive than RNS for all grades of OMG. Furthermore, if a complete SFEMG study is normal, addition of RNS does not improve the diagnostic yield.
我们旨在确定重复神经电刺激研究（RNS）是否能提高单纤维肌电图（SFEMG）对不同程度眼肌型重症肌无力（OMG）的诊断阳性率。
121例根据临床标准诊断为轻度、中度或重度OMG的患者接受了额肌的SFEMG检查和面神经的RNS检查。通过列联表分析比较检查结果。
在这些患者中，19%的患者RNS异常，95%的患者SFEMG异常。轻度、中度和重度OMG患者中SFEMG异常的比例分别为93%、96%和100%。1例RNS异常的患者SFEMG正常，但SFEMG检查不完整。
与全身型重症肌无力一样，SFEMG对所有程度的OMG都比RNS更敏感。此外，如果完整的SFEMG检查正常，增加RNS检查并不能提高诊断阳性率。
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