France James E, Beech Fiona J M, Jakeman Nicola, Benger Jonathan R
Emergency Department, Royal United Hospital, Combe Park, Bath, UK.
Eur J Emerg Med. 2008 Aug;15(4):218-20. doi: 10.1097/MEJ.0b013e3282f4d19b.
To determine whether the use of ethyl chloride and subcutaneous lidocaine are associated with a reduction in pain during arterial blood sampling compared with using no local anaesthesia.
Patients over the age of 16 years and who required arterial blood sampling as part of their on-going emergency department management were randomly allocated to one of three groups. Group A received routine skin preparation before arterial puncture (AP); group B received 0.5 ml of 2% lidocaine 2 min before AP; and group C received ethyl chloride immediately before AP. Pain was measured using 100-mm visual analogue scale.
Two urban emergency departments.
Fifty-four patients were recruited. Those receiving lidocaine before AP had lower pain scores [10.2 mm, 95% confidence interval (CI): 4.8-16.3 mm] compared with the use of ethyl chloride (23.9 mm, 95% CI: 12.4-35.5 mm) and nothing (23.4 mm, 95% CI: 11.7-35.0 mm). Lidocaine was more painful to administer (22.0 mm, 95% CI: 10.9-33.7 mm) compared with ethyl chloride (12.9 mm, 95% CI: 5.5-20.3 mm).
Ethyl chloride is not an effective local anaesthetic agent for AP. When the pain of local anaesthetic administration is taken into account the benefit of subcutaneous lidocaine for single AP is limited.
确定与不使用局部麻醉相比,使用氯乙烷和皮下注射利多卡因是否能减轻动脉采血时的疼痛。
年龄在16岁以上且因急诊持续治疗需要进行动脉采血的患者被随机分为三组。A组在动脉穿刺(AP)前接受常规皮肤准备;B组在AP前2分钟接受0.5毫升2%的利多卡因;C组在AP前立即接受氯乙烷。使用100毫米视觉模拟量表测量疼痛程度。
两个城市急诊科。
共招募了54名患者。与使用氯乙烷(23.9毫米,95%置信区间[CI]:12.4 - 35.5毫米)和不使用任何麻醉剂(23.4毫米,95% CI:11.7 - 35.0毫米)相比,在AP前接受利多卡因的患者疼痛评分更低[10.2毫米,95% CI:4.8 - 16.3毫米]。与氯乙烷(12.9毫米,95% CI:5.5 - 20.3毫米)相比,注射利多卡因时更疼(22.0毫米,95% CI:10.9 - 33.7毫米)。
氯乙烷不是一种有效的动脉穿刺局部麻醉剂。考虑到局部麻醉剂注射时的疼痛,皮下注射利多卡因对单次动脉穿刺的益处有限。