Irkoren Saime, Ozkan Heval Selman, Karaca Huray
From the Department of Plastic and Reconstructive Surgery, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
Ann Plast Surg. 2015 Sep;75(3):272-4. doi: 10.1097/SAP.0000000000000121.
This study aims to analyze the efficiency of EMLA cream and ethyl chloride spray application for pain alleviation before botulinum toxin injection.
Forty-five patients were divided into 3 treatment groups. Skin cooling with ethyl chloride spray (in group 1), topical anesthetic cream (EMLA) (in group 2), was used on the forehead area on one side previous to injection; the opposite side served as the control. In the third group (n = 15), cold was applied using ethyl chloride spray to one side, and to the other side topical anesthetic cream (EMLA) was applied. A visual analog scale was used for pain intensity.
In the first group, the average pain score was 3.20 ± 1.20 on the side where ethyl chloride spray was applied and 7.26 ± 1.94 on the control side (P < 0.05). It was 4.20 ± 1.37 on the side receiving EMLA and 7.66 ± 1.54 (P < 0.05) on the control side in the second group. In the third group, the average score was 6.80 ± 1.37 for the EMLA side and 2.93 ± 1.03 for the ethyl chloride sprayed side (P < 0.05).
Skin cooling with ethyl chloride spray significantly decreases the pain associated during forehead botulinum toxin injections.
本研究旨在分析在注射肉毒杆菌毒素前使用复方利多卡因乳膏和氯乙烷喷雾剂缓解疼痛的效果。
45例患者被分为3个治疗组。在注射前，第1组使用氯乙烷喷雾剂对一侧前额区域进行皮肤冷却，第2组使用外用麻醉乳膏（复方利多卡因乳膏），另一侧作为对照。在第3组（n = 15）中，一侧使用氯乙烷喷雾剂进行冷却，另一侧使用外用麻醉乳膏（复方利多卡因乳膏）。采用视觉模拟量表评估疼痛强度。
在第1组中，使用氯乙烷喷雾剂一侧的平均疼痛评分为3.20±1.20，对照侧为7.26±1.94（P < 0.05）。在第2组中，使用复方利多卡因乳膏一侧的评分为4.20±1.37，对照侧为7.66±1.54（P < 0.05）。在第3组中，复方利多卡因乳膏一侧的平均评分为6.80±1.37，氯乙烷喷雾剂一侧为2.93±1.03（P < 0.05）。
使用氯乙烷喷雾剂进行皮肤冷却可显著减轻前额注射肉毒杆菌毒素时的相关疼痛。
