Hayaishi O
Osaka Bioscience Institute, Japan.
FASEB J. 1991 Aug;5(11):2575-81.
Although sleep-wake cycles are repeated every day and night and almost one-third of our lifetime is spent sleeping, the molecular mechanisms of sleep-wake regulation have remained little understood. Recent experimental evidence indicates that prostaglandins (PG) D2 and E2 are probably two of the major endogenous sleep-regulating substances, one promoting sleep and the other wakefulness, in rats, dogs, rabbits, monkeys, and probably in humans as well. Preliminary evidence indicates that the sites of action of PGD2 and E2 are located in the sleep and wake centers in or near the preoptic area and posterior hypothalamus, respectively.
尽管昼夜睡眠-清醒周期每天重复进行，且我们一生中有近三分之一的时间用于睡眠，但睡眠-清醒调节的分子机制仍鲜为人知。最近的实验证据表明，前列腺素（PG）D2和E2可能是大鼠、狗、兔子、猴子以及可能在人类中调节睡眠的两种主要内源性物质，一种促进睡眠，另一种促进清醒。初步证据表明，PGD2和E2的作用位点分别位于视前区和下丘脑后部或其附近的睡眠和清醒中枢。
