中缝大核的可逆性失活和兴奋可调节雄性Wistar大鼠在低温状态下的尾部血流量。
Reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male Wistar rats in response to hypothermia.
作者信息
Malakouti Seyed Mansour, Kourosh Arami Masoomeh, Sarihi Abdorahman, Hajizadeh Sohrab, Behzadi Gila, Shahidi Siamak, Komaki Alireza, Heshmatian Behnam, Vahabian Mehrangiz
机构信息
Dept. of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Dept. of Physiology, Tarbiat Modares University, Tehran, Iran.
出版信息
Iran Biomed J. 2008 Oct;12(4):203-208.
BACKGROUND
The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus.
INTRODUCTION
we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia.
METHODS
Hypothermia was induced in Male Wistar rats and cannula was implanted above the NRM. To evaluate the effect of nucleus inactivation on TBF, the amount of TBF was measured by Laser Doppler in hypothermic rats, before and after lidocaine microinjection into NRM. TBF was also measured after glutamate microinjection to assess the effect of nucleus excitation in hypothermic rats.
RESULTS
Results indicated that after dropping TBF by hypothermia, microinjection of lidocaine into NRM significantly decreased TBF from 54.43 +- 5.7 to 46.81 +- 3.4, whereas glutamate microinjection caused a significant increase from 44.194 +- 0.6 to 98 +- 10.0 CONCLUSION: These data suggest that NRM have thermoregulatory effect in response to hypothermia.
背景
中缝大核（NRM）参与体温调节过程。NRM中细胞放电频率的变化与外周热刺激的施加之间存在相关性。
引言
我们研究了NRM可逆性失活和兴奋对低温状态下尾血流量（TBF）调节机制的影响。
方法
对雄性Wistar大鼠诱导低温，并在NRM上方植入套管。为评估核失活对TBF的影响，在低温大鼠中，于向NRM微量注射利多卡因前后，通过激光多普勒测量TBF量。还在微量注射谷氨酸后测量TBF，以评估低温大鼠中核兴奋的影响。
结果
结果表明，在低温导致TBF下降后，向NRM微量注射利多卡因使TBF从54.43±5.7显著降至46.81±3.4，而微量注射谷氨酸则使其从44.194±0.6显著增至98±10.0。结论：这些数据表明NRM在低温反应中具有体温调节作用。
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