Liu Xiao-wei, Xu Jing, Zhang Bing-wei, Zhao Lun, Li Qing-dong, Jiang Guo-jing
Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Zhonghua Yi Xue Za Zhi. 2008 Nov 11;88(41):2912-5.
To investigate the electrophysiological evidence of inhibitory control deficit in panic disorder patients using a visual simple Go/Nogo task.
Sixteen patients with panic disorder and 13 healthy volunteers received a visual simple Go/Nogo task. The stimuli were single or double English letters and appeared with equal probability. The subjects were instructed to press a button as quickly as possible when the double letter was presented (i.e., Go), but make no response to the single letter (i.e., Nogo). 32 channel EEG data were recorded.
All subjects displayed a distinct Go/Nogo effect in the N2 component (PD group:F(1,30) = 8.00, P = 0.008; NC group: F(1,24) = 4.60, P = 0.042) and P3 component (PD group: F(1,30) = 7.85, P = 0.009; NC group: F(1,24) = 13.57, P = 0.000) at frontocentral sites, but the amplitudes of Nogo-N2 and Nogo-P3 were significantly reduced in panic disorder patients as compared to the healthy subjects (Fz: F = 9.135, P = 0.005; F = 8.511, P = 0.006, respectively). There was no significant differences between the latencies of Nogo-N2 and Nogo-P3.
Panic disorder may consist inhibitory control deficit which may assist in offering new objective evidence to understand the etiology of panic disorder.
使用视觉简单Go/Nogo任务探究惊恐障碍患者抑制控制缺陷的电生理证据。
16名惊恐障碍患者和13名健康志愿者接受视觉简单Go/Nogo任务。刺激物为单个或双个英文字母，出现概率相等。受试者被要求在出现双字母时尽快按下按钮（即Go），但对单字母不做反应（即Nogo）。记录32通道脑电图数据。
所有受试者在额中央部位的N2成分（惊恐障碍组：F(1,30) = 8.00，P = 0.008；正常对照组：F(1,24) = 4.60，P = 0.042）和P3成分（惊恐障碍组：F(1,30) = 7.85，P = 0.009；正常对照组：F(1,24) = 13.57，P = 0.000）均表现出明显的Go/Nogo效应，但与健康受试者相比，惊恐障碍患者的Nogo-N2和Nogo-P3波幅显著降低（Fz部位：F分别为9.135，P = 0.005；F为8.511，P = 0.006）。Nogo-N2和Nogo-P3的潜伏期之间无显著差异。
惊恐障碍可能存在抑制控制缺陷，这可能有助于为理解惊恐障碍的病因提供新的客观证据。
