López Mollá Celia, Estellés Ferriol Enrique, Carrasco Llatas Marina, Seijas Rosales Teresa, Morales Suárez-Varela María, Dalmau Galofre José
Servicio de Otorrinolaringología, Hospital Universitario Dr. Peset, Valencia, España.
Acta Otorrinolaringol Esp. 2008 Nov;59(9):427-32.
The incidence of multiple malignant neoplasms in the upper aerodigestive tract is high and ranges from 7% to 20%. We make a retrospective study to evaluate the incidence of multiple malignant neoplasms in head and neck squamous cell carcinomas, their main characteristics and survival.
We studied 103 multiple malignant neoplasms from an oncological database of 1330 patients with head and neck squamous cell carcinomas. We use the SPSS v15 for analysis of the results.
The incidence of multiple malignant neoplasms in our series is 7.73 %. Tumours of the hypopharynx are the primary tumours most often associated with multiple malignant neoplasms (21.34 %), followed by tumours of the oropharynx (15.38 %). Lung tumours are the multiple malignant neoplasms most often associated (29.03 %). The 5-year global survival is 33 % from diagnosis of the second primary tumour, 78.02 % of which are metachronous with an average of 40 months between the diagnosis of the primary tumour and the presentation of the second tumour.
Multiple malignant neoplasms are very frequent in the head and neck area which shows the importance of thorough regular check-ups of these patients as the presence of multiple malignant neoplasms considerably worsens the prognosis.
上呼吸道消化道多原发恶性肿瘤的发病率较高，在7%至20%之间。我们进行了一项回顾性研究，以评估头颈部鳞状细胞癌多原发恶性肿瘤的发病率、主要特征及生存率。
我们从1330名头颈部鳞状细胞癌患者的肿瘤数据库中研究了103例多原发恶性肿瘤。我们使用SPSS v15对结果进行分析。
我们系列研究中多原发恶性肿瘤的发病率为7.73%。下咽肿瘤是最常与多原发恶性肿瘤相关的原发肿瘤（21.34%），其次是口咽肿瘤（15.38%）。肺部肿瘤是最常伴发的多原发恶性肿瘤（29.03%）。从诊断第二原发肿瘤起，5年总生存率为33%，其中78.02%为异时性肿瘤，原发肿瘤诊断与第二肿瘤出现之间的平均间隔为40个月。
多原发恶性肿瘤在头颈部区域非常常见，这表明对这些患者进行彻底定期检查的重要性，因为多原发恶性肿瘤的存在会显著恶化预后。
