Mutschler Jochen, Diehl Alexander, Vollmert Christian, Herre Hans, Mann Karl, Kiefer Falk
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Mannheim.
Neuropsychiatr. 2008;22(4):243-51.
For more than 50 years, disulfiram has been approved for the treatment of chronic alcohol dependence. In the last years there has been observed an increase in the prescription of disulfiram in germany. It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram.
Clinical trials using disulfiram for the treatment of alcohol dependence were discussed. Furthermore, the options of combining disulfiram with novel anti-craving agents were considered. Moreover, experiences and results of a cross section of the Mannheimer Disulfiram program will be presented.
Nowadays there exists consent in the matter that Disulfiram should only be adminsitered as part of a comprehensive therapy program, this means in the context of an intake under medical supervision. This paper is supposed to help estimate the value of disulfiram in recent addiction medicine.
五十多年来，双硫仑已被批准用于治疗慢性酒精依赖。近年来，德国双硫仑的处方量有所增加。它起到对可能的双硫仑-酒精反应的心理威慑作用。本文描述了双硫仑当前的临床影响及可能的未来发展。
讨论了使用双硫仑治疗酒精依赖的临床试验。此外，还考虑了将双硫仑与新型抗渴求药物联合使用的选择。此外，还将介绍曼海姆双硫仑项目的一些经验和结果。
如今，人们一致认为双硫仑仅应作为综合治疗方案的一部分使用，也就是说应在医疗监督下服用。本文旨在帮助评估双硫仑在当代成瘾医学中的价值。
