Fournel I, Soulias M, Bour J-B, Gouyon J-B, Huet F, Aho L-S
Service d'hygiène et d'épidémiologie hospitalière, pôle des pathologies lourdes et des vigilances, CHU de Dijon, 1, boulevard Jeanne-d'Arc, 21079 Dijon cedex, France.
Pathol Biol (Paris). 2010 Dec;58(6):406-14. doi: 10.1016/j.patbio.2008.10.003. Epub 2008 Dec 9.
Respiratory syncytial virus (RSV) and Rotavirus infections represent up to 30% of cross infections in pediatric units. As they are a major public health problem, we studied their evolution and distribution at the Dijon University Hospital.
This exhaustive retrospective study included children under 15 with a new Rotavirus or RSV infection who were hospitalised at the Dijon University Hospital between 1998 and 2005. The general trend was determined by using moving averages, and the Spearman correlation coefficient r(s) was calculated.
From 1998 to 2005, 1886 new RSV (n=981) or Rotavirus (n=905) infections were identified in hospitalised children. The number of the infections decreased significantly, both for RSV (r(s)=-0.71 ; p<0.0001) and for Rotavirus (r(s)=-0.77 ; p<0.0001). Almost half of Rotavirus infections were nosocomial (46.3%) vs 5.3% of RSV infections, p<0.0001. There was no significant difference in the proportion of RSV nosocomial infections between the epidemic and non-epidemic period (4.9% of nosocomial infections vs 7.1% respectively, p=0.25). Rotavirus nosocomial infections were less frequent in epidemic period (41.6%) than in non-epidemic period (54.6%); p=0.0002.
RSV and Rotavirus infections significantly decreased between 1998 and 2005. Proportion of RSV or Rotavirus infections didn't increase in epidemic period, which could be explained both by an increased attention from healthcare professionals and by the effectiveness of hygiene measures taken.
呼吸道合胞病毒（RSV）和轮状病毒感染占儿科病房交叉感染的30%。由于它们是一个重大的公共卫生问题，我们研究了第戎大学医院中它们的演变和分布情况。
这项详尽的回顾性研究纳入了1998年至2005年间在第戎大学医院住院的15岁以下新感染轮状病毒或RSV的儿童。通过移动平均数确定总体趋势，并计算斯皮尔曼相关系数r(s)。
1998年至2005年间，在住院儿童中发现了1886例新的RSV感染（n = 981）或轮状病毒感染（n = 905）。RSV感染（r(s)= -0.71；p<0.0001）和轮状病毒感染（r(s)= -0.77；p<0.0001）的数量均显著下降。几乎一半的轮状病毒感染是医院感染（46.3%），而RSV感染为5.3%，p<0.0001。RSV医院感染在流行期和非流行期的比例无显著差异（医院感染分别为4.9%和7.1%，p = 0.25）。轮状病毒医院感染在流行期（41.6%）比非流行期（54.6%）更少见；p = 0.0002。
1998年至2005年间，RSV和轮状病毒感染显著减少。RSV或轮状病毒感染在流行期的比例没有增加，这可能是由于医护人员关注度提高以及所采取的卫生措施有效。
