Randić Milan, Mehulić Ketij, Vukicević Damir, Pisanski Tomaz, Vikić-Topić Drazen, Plavsić Dejan
National Institute of Chemistry, 1001 Ljubljana, Slovenia.
J Mol Graph Model. 2009 Jan;27(5):637-41. doi: 10.1016/j.jmgm.2008.10.004. Epub 2008 Nov 1.
We put forward a novel compact 2-D graphical representation of proteins based on the concept of virtual genetic code and a four-color map. The novel graphical representation uniquely represents proteins and allows one to easily and quickly visually observe and inspect similarity/dissimilarity between them. It also leads to a novel protein descriptor, a 10-dimensional vector derived from a novel structure matrix S associated with the map. The introduced numerical characterization of proteins is not only useful for their comparative study, but also for cataloguing information on a single protein. The approach is illustrated with the A chain of human insulin and the A chain of human insulin analogue glargine.
我们基于虚拟遗传密码的概念和四色图谱提出了一种新颖的蛋白质二维紧凑图形表示法。这种新颖的图形表示法能唯一地表示蛋白质，使人们能够轻松快速地直观观察和检查它们之间的相似性/差异性。它还引出了一种新颖的蛋白质描述符，即从与该图谱相关的新颖结构矩阵S导出的十维向量。所引入的蛋白质数值表征不仅对其比较研究有用，而且对单个蛋白质的信息编目也有用。用人胰岛素A链和甘精胰岛素类似物的A链对该方法进行了说明。
