Ikiz Burcin, Przedborski Serge
Department of Neurology, Pathology, and Cell Biology and Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
Neuron. 2008 Dec 10;60(5):731-2. doi: 10.1016/j.neuron.2008.11.020.
p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.
p25/Cdk5功能失调可能导致神经退行性变。在本期《神经元》杂志中，金等人表明Cdk5使组蛋白去乙酰化酶-1（HDAC-1）失活，导致细胞周期失调和DNA损伤积累。这项研究进一步深入了解了p25/Cdk5在神经元中的功能，并指出HDAC-1可作为治疗干预的靶点。
