Gadjev Ilya, Stone Julie M, Gechev Tsanko S
Department of Plant Physiology and Plant Molecular Biology, University of Plovdiv, Plovdiv 4000, Bulgaria.
Int Rev Cell Mol Biol. 2008;270:87-144. doi: 10.1016/S1937-6448(08)01403-2.
Programmed cell death (PCD), the highly regulated dismantling of cells, is essential for plant growth and survival. PCD plays key roles in embryo development, formation and maturation of many cell types and tissues, and plant reaction/adaptation to environmental conditions. Reactive oxygen species (ROS) are not only toxic by products of aerobic metabolism with strictly controlled cellular levels, but they also function as signaling agents regulating many biological processes and producing pleiotropic effects. Over the last decade, ROS have become recognized as important modulators of plant PCD. Molecular genetic approaches using plant mutants and transcriptome studies related to ROS-mediated PCD have revealed a wide array of plant-specific cell death regulators and have contributed to unraveling the elaborate redox signaling network. This review summarizes the biological processes, in which plant PCD participates and discusses the signaling functions of ROS with emphasis on hydrogen peroxide.
程序性细胞死亡（PCD），即细胞的高度调控性解体，对植物的生长和存活至关重要。PCD在胚胎发育、多种细胞类型和组织的形成与成熟以及植物对环境条件的反应/适应过程中发挥着关键作用。活性氧（ROS）不仅是需氧代谢的有毒副产物，其细胞水平受到严格控制，而且它们还作为信号分子发挥作用，调节许多生物学过程并产生多效性影响。在过去十年中，ROS已被公认为植物PCD的重要调节因子。利用植物突变体的分子遗传学方法以及与ROS介导的PCD相关的转录组研究，揭示了大量植物特有的细胞死亡调节因子，并有助于阐明复杂的氧化还原信号网络。本综述总结了植物PCD参与的生物学过程，并重点讨论了ROS尤其是过氧化氢的信号功能。
