Juntas Morales R, Tillier J-N, Davous P
centre hospitalier Victor-Dupouy, Argenteuil, France.
Rev Neurol (Paris). 2009 Oct;165(10):836-8. doi: 10.1016/j.neurol.2008.10.016. Epub 2008 Dec 10.
Primo-infection by varicella-zoster virus (VZV) may be associated with several neurologic complications. Bilateral facial palsy is a rather uncommon manifestation.
We report the case of a 38-year-old woman who developed bilateral facial diplegia and paresthesia affecting all four limbs with subacute onset several days after varicella virus primoinfection. Ancillary tests showed hyperproteinorachia and signs of demyelinating polyneuropathy in nerve conduction tests. The diagnosis of Guillain-Barré syndrome was retained and a treatment with intravenous immunoglobulines was started, leading to progressive improvement.
Immunotherapy is a possible therapeutic approach in the context of neurologic postinfectious complications after VZV infection where an underlying mechanism is probable.
水痘-带状疱疹病毒(VZV)的初次感染可能与多种神经系统并发症相关。双侧面神经麻痹是一种相当罕见的表现。
我们报告一例38岁女性,在水痘病毒初次感染几天后,亚急性起病,出现双侧面瘫以及累及四肢的感觉异常。辅助检查显示脑脊液蛋白含量增高,神经传导检查有脱髓鞘性多发性神经病的表现。诊断为吉兰-巴雷综合征,并开始静脉注射免疫球蛋白治疗,病情逐渐好转。
在VZV感染后可能存在潜在机制的神经系统感染后并发症的情况下,免疫疗法是一种可行的治疗方法。