Atsumi Masahiko, Kitaguchi Masataka, Chimoto Yuko, Nishikawa Shogo, Mineta Haruyuki, Nakasaka Yoshikuni, Tanaka Hisashi, Susuki Keiichiro
Department of Neurology, Baba Memorial Hospital.
Rinsho Shinkeigaku. 2003 Sep;43(9):548-51.
We described a patient with ataxic Guillain-Barré syndrome who subsequently developed facial diplegia. A 38-year-old man developed ataxia, distal limb paresthesias, mild dysphagia, urinary retention and orthostatic hypotension a week after an episode of laryngitis. He had high titers of serum anti-GQ1b, anti-GD1b, anti-GM1b, anti-GT1a, and anti-GD1a IgG antibodies during the acute phase. Although the initial symptoms markedly improved by intravenous immunoglobulin therapy, asymmetric facial diplegia subsequently occurred and remained longer than ataxia. Similar course of facial nerve palsy has been reported in patients with Fisher syndrome. Common pathophysiological mechanism may function in the development of delayed facial diplegia in Fisher syndrome and ataxic Guillain-Barre syndrome.
我们描述了一名患有共济失调性吉兰-巴雷综合征的患者，该患者随后出现了双侧面瘫。一名38岁男性在一次喉炎发作一周后出现共济失调、肢体远端感觉异常、轻度吞咽困难、尿潴留和体位性低血压。急性期时，他的血清抗GQ1b、抗GD1b、抗GM1b、抗GT1a和抗GD1a IgG抗体滴度很高。尽管通过静脉注射免疫球蛋白治疗，初始症状明显改善，但随后出现了不对称性双侧面瘫，且持续时间比共济失调更长。在费舍尔综合征患者中也报道过类似的面神经麻痹病程。费舍尔综合征和共济失调性吉兰-巴雷综合征中延迟性双侧面瘫的发生可能存在共同的病理生理机制。
