Hu H P, Slooff T J, van Horn J R
Institute for Orthopedics, St. Radboud Hospital, University of Nijmegen, The Netherlands.
Acta Orthop Belg. 1991;57(2):169-82.
Heterotopic ossification is the most frequent complication of total hip arthroplasty. When formed in the para-articular tissues, it may cause pain and restriction of hip motion. The present article extensively reviews the current literature on heterotopic ossification following total hip arthroplasty with regard to epidemiologic factors, clinical presentation and possible pathogenesis. Preventive measures are emphasized. Postoperative treatment with radiation and nonsteroidal antiinflammatory drugs have yielded good results in the prevention of heterotopic ossification. On the other hand, biophosphonates were ineffective. In comparison with radiation therapy, prophylaxis with nonsteroidal antiinflammatory drugs gave better results. Further research is still needed to define the most effective and safe medication regimen.
异位骨化是全髋关节置换术最常见的并发症。当在关节周围组织中形成时，它可能会引起疼痛和髋关节活动受限。本文广泛综述了目前关于全髋关节置换术后异位骨化的文献，涉及流行病学因素、临床表现和可能的发病机制，并强调了预防措施。术后使用放射治疗和非甾体类抗炎药在预防异位骨化方面取得了良好效果。另一方面，双膦酸盐无效。与放射治疗相比，使用非甾体类抗炎药进行预防效果更好。仍需要进一步研究来确定最有效和安全的药物治疗方案。
