陶瓷菌素B-D，来自菲律宾红楝子的新型抗疟柠檬苦素。
Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus.
作者信息
Mohamad Khalit, Hirasawa Yusuke, Litaudon Marc, Awang Khalijah, Hadi A Hamid A, Takeya Koichi, Ekasari Wiwied, Widyawaruyanti Aty, Zaini Noor Cholies, Morita Hiroshi
机构信息
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.
出版信息
Bioorg Med Chem. 2009 Jan 15;17(2):727-30. doi: 10.1016/j.bmc.2008.11.048. Epub 2008 Nov 24.
PMID:19081726
Abstract
Three new limonoids, ceramicines B-D (1-3), have been isolated from the bark of Chisocheton ceramicus. Structures and stereochemistry of 1-3 were fully elucidated and characterized by 2D NMR analysis. Ceramicines exhibited a moderate antiplasmodial activity.
摘要
从菲律宾天料木的树皮中分离出了三种新的柠檬苦素，即陶瓷菌素B-D（1-3）。通过二维核磁共振分析对1-3的结构和立体化学进行了全面阐释和表征。陶瓷菌素表现出中等程度的抗疟活性。
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