Wong Chin Piow, Shimada Misae, Nagakura Yuta, Nugroho Alfarius Eko, Hirasawa Yusuke, Kaneda Toshio, Awang Khalijah, Hadi A Hamid A, Mohamad Khalit, Shiro Motoo, Morita Hiroshi
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 2011;59(3):407-11. doi: 10.1248/cpb.59.407.
Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.
从菲律宾红椿树皮中分离出了5种新的柠檬苦素类化合物，即菲律宾红椿素E - I（1 - 5）。基于一维和二维核磁共振数据，对它们的结构和相对立体化学进行了全面解析。菲律宾红椿素E - I（1 - 5）对一系列细胞系（HL - 60、A549、MCF7和HCT116）表现出中等程度的细胞生长抑制活性。通过圆二色光谱（CD）和X射线分析也阐明了先前分离出的菲律宾红椿素B（6）的绝对结构。
