Horn Charles C
Monell Chemical Senses Center, Philadelphia, PA 19104 USA.
Drug Discov Today Ther Strateg. 2007;4(3):183-187. doi: 10.1016/j.ddstr.2007.09.002.
Nausea and vomiting occur in a large number of disease conditions and as side effects of many drug treatments, including use of analgesics and anesthesia in surgery and chemotherapy in cancer treatment. Current anti-emetics provide relief from only some sources of vomiting, with more limited benefits for the control of nausea. Elucidation of forebrain pathways that generate nausea and brainstem circuitry controlling emesis are significant obstacles for the development of effective universal anti-nausea and anti-emetic treatments.
恶心和呕吐在大量疾病状态中都会出现，并且作为许多药物治疗的副作用，包括手术中使用镇痛药和麻醉药以及癌症治疗中的化疗。目前的止吐药仅能缓解部分呕吐原因，对控制恶心的效果更为有限。阐明引发恶心的前脑通路和控制呕吐的脑干神经回路是开发有效的通用抗恶心和止吐治疗方法的重大障碍。
